儿童周期性发热、口疮性口炎、咽炎和宫颈腺炎综合征:简要文献综述

IF 1.4 Q3 PEDIATRICS Revista Paulista De Pediatria Pub Date : 2022-06-10 DOI:10.1590/1984-0462/2022/40/2021087IN
C. Okamoto, Hanne Lise Chaves, Mateus José Schmitz
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引用次数: 2

摘要

摘要目的:探讨周期性发热、口疮性口炎、咽炎和宫颈腺炎(PFAPA)综合征的临床、诊断和治疗特点。数据来源:PubMed数据库中的文献综述,通过使用特定的描述符识别近三年内以英语发表的所有文章;共发现38件物品。在进行标题选择和摘要分析后,38篇文章中有13篇被完全阅读。同时纳入了被审稿文章参考文献中的相关研究。资料综合:PFAPA综合征(周期性发热、口疮性口炎、咽炎和宫颈腺炎)是一种属于周期性发热综合征的医学病症。病因不确定,但可能是多因素的,其症状伴有反复发热发作,但体重和身高的发展保持不变。它是一种自限性的良性疾病,病程可缓解2 - 3年,对患者的整体发展无明显干扰。治疗包括三个支柱:发热发作的中断,发作间隔的增加和缓解。结论:尽管多次尝试建立更敏感和特异性的标准,但PFAPA综合征的诊断仍然是临床根据修改后的Marshall标准进行排除。最常见的药物治疗方案包括强的松和倍他米松;秋水仙碱可用于预防,在选定的病例中可考虑扁桃体切除术的手术治疗。
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Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome in children: a brief literature review
ABSTRACT Objective: To describe clinical, diagnostic and therapeutic characteristics of the periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome. Data source: Literature review in the PubMed database by using specific descriptors to identify all articles published in the English language in the last three years; 38 articles were found. After performing selection of titles and abstract analysis, 13 out of the 38 articles were fully read. Relevant studies found in the references of the reviewed articles were also included. Data synthesis: The PFAPA syndrome (Periodic Fever, Aphthous Stomatitis, Pharyngitis and cervical Adenitis) is a medical condition grouped among the periodic fever syndromes. The etiology is uncertain, but possibly multifactorial, and its symptoms are accompanied by recurrent febrile episodes although weight and height development are preserved. It is a self-limiting disease of benign course with remission of two to three years without significant interference in the patient's overall development. Treatment consists of three pillars: interruption of febrile episodes, increase in the interval between episodes, and remission. Conclusions: Despite several attempts to establish more sensitive and specific criteria, the diagnosis of PFAPA syndrome is still clinical and reached by exclusion, based on the modified Marshall's criteria. The most common pharmacological options for treatment include prednisolone and betamethasone; colchicine may be used as prophylaxis, and surgical treatment with tonsillectomy can be considered in selected cases.
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来源期刊
Revista Paulista De Pediatria
Revista Paulista De Pediatria Medicine-Pediatrics, Perinatology and Child Health
CiteScore
2.30
自引率
0.00%
发文量
100
审稿时长
11 weeks
期刊介绍: The Revista Paulista de Pediatria publishes original contributions, case reports and review of clinical research with methodological approach in the areas of health and disease of neonates, infants, children and adolescents. The objective is to disseminate research with methodological quality on issues that comprise the health of children and adolescents. All articles are freely available online, via SciELO. Its abbreviated title is Rev. Paul. Pediatr., which should be used in bibliographies, footnotes and bibliographical references and strips.
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