含有光敏剂的生物组织中发生的现象的数学建模

M. Jasiński, Maria Zadoń
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引用次数: 0

摘要

. 本研究的目的是分析光动力治疗(PDT)过程中发生的光热和光化学现象。在这种类型的治疗中,在激光的影响下,发生与三重态氧形式转化为单线态氧形式有关的反应,这对组织具有细胞毒性。PDT过程中激光与组织相互作用引起的温度升高幅度不大;然而,它们会导致组织灌注的改变,从而影响组织的氧气输送。该模型采用光学扩散方程、Pennes生物传热方程和PDT反应方程。分析的主要结果表明,在处理过程结束时,温度对灌注系数值和三重态氧分布的影响。
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Mathematical modeling of the phenomena that occur in a biological tissue containing photosensitizer
. The aim of the study is to analyze photothermal and photochemical phenomena that occur during photodynamic therapy (PDT). In this type of therapy, under the influence of the laser, reactions take place related to the transformation of triplet oxygen form into its singlet form which is cytotoxic to the tissue. The increases in temperature resulting from the laser-tissue interaction during PDT are not big; however, they can lead to changes in tissue perfusion, which can affect oxygen delivery to the tissue. The proposed model uses optical diffusion equation, Pennes bioheat transfer equation, and reactions equations for PDT. The main findings of the analysis show the impact of temperature on the value of the perfusion coefficient and triplet oxygen distributions at the end of the treatment procedure.
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来源期刊
CiteScore
2.00
自引率
10.00%
发文量
30
审稿时长
25 weeks
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