瑞德西韦从抑制丙型肝炎病毒到治疗新冠肺炎的历程

IF 1.3 4区 医学 Q4 INFECTIOUS DISEASES Antiviral Therapy Pub Date : 2022-02-01 DOI:10.1177/13596535221082773
T. Cihlar, R. Mackman
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引用次数: 7

摘要

如果一条计划好的路走到了尽头,你可以简单地停下来。或者可以转身,走回最后一个十字路口,走另一条路,或者可以考虑走几条平行的路。最后一种情况反映了第一种治疗新冠肺炎的抗病毒药物瑞德西韦的历程,该药物在导致新冠肺炎大流行的病毒SARS-CoV-2分离后不到10个月就获得了FDA的批准。截至2022年1月,全球已有1000万新冠肺炎患者接受了瑞德西韦治疗,但这种分子的旅程始于十多年前,当时正在寻找丙型肝炎病毒的治疗方法。新冠肺炎出现前的瑞德西韦开发道路代表了先发制人的大流行准备的一个宝贵例子,但如果没有约翰·C·马丁的持续支持,这条道路是不可能实现的,我们将非常怀念他敏锐的眼光、毫不妥协的领导能力和对世界各地受苦受难的患者的真诚同情。
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Journey of remdesivir from the inhibition of hepatitis C virus to the treatment of COVID-19
If a planned path reaches a dead-end, one can simply stop. Or one can turn around, walk back to the last intersection and take another path, or one can consider taking few paths in parallel. The last scenario is reflective of the journey of remdesivir, the first antiviral for the treatment of COVID-19, that was approved by FDA less than 10 months after the isolation of SARS-CoV-2, the virus responsible for the COVID-19 pandemic. As of January 2022, 10 million COVID-19 patients have been treated with remdesivir worldwide, but the journey of this molecule started more than a decade earlier with the search for a cure of hepatitis C virus. The development path of remdesivir before the emergence of COVID-19 represents a valuable example of a preemptive pandemic preparedness, but the pursuit of this path would not have been possible without sustaining support of John C. Martin, whom we will sorely miss for his piercing vision, uncompromising leadership, and genuine compassion for patients suffering around the world.
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来源期刊
Antiviral Therapy
Antiviral Therapy 医学-病毒学
CiteScore
2.60
自引率
8.30%
发文量
35
审稿时长
4-8 weeks
期刊介绍: Antiviral Therapy (an official publication of the International Society of Antiviral Research) is an international, peer-reviewed journal devoted to publishing articles on the clinical development and use of antiviral agents and vaccines, and the treatment of all viral diseases. Antiviral Therapy is one of the leading journals in virology and infectious diseases. The journal is comprehensive, and publishes articles concerning all clinical aspects of antiviral therapy. It features editorials, original research papers, specially commissioned review articles, letters and book reviews. The journal is aimed at physicians and specialists interested in clinical and basic research.
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