急性肺栓塞和血压正常患者右心室功能障碍的预后价值

M. Hassine, S. Lamine, M.Y. Kallala, S. Kraeim, N. Bouchehda, M.M. Boussaada, M. Ben Messoud, M. Mahjoub, H. Gamra
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引用次数: 0

摘要

超声心动图右室(RV)功能障碍在预测临床稳定的肺栓塞(PE)患者临床结局中的作用尚不明确。在这项研究中,我们在广泛的PE患者中评估了血压正常的右心室功能障碍患者的患病率和临床结果。方法回顾性临床结局研究纳入186例连续的PE患者(年龄:62±15岁)。急性左室功能障碍诊断有以下一项或多项标准:左室间隔外径/左室间隔外径>TTE或CT 4房位0.9,右心室收缩(TAPSE <肺动脉高压的多普勒证据(PASP >40 mmHg)和/或悖论性室间隔收缩运动。结果78例患者诊断为右心室功能障碍(47.3%)。两组患者在年龄、性别、深静脉血栓(DVT)患病率、癌症及其他危险因素方面均无差异。住院死亡率(21.6% vs. 5.4%;P = 0.001)、心源性休克(P = 0.001)和溶栓治疗(P = 0.004)在RV功能障碍患者中的发生率显著高于其他组。多因素logistic回归模型显示右心室功能障碍与住院死亡率之间存在显著相关性(OR: 3.815, 95% CI: 1.012-10.47, P = 0.001)。结论在正常血压的急性肺心病患者中,有显著比例(47%)存在右心室功能障碍;这些有潜在血流动力学障碍的患者有更多的pe相关休克和住院死亡率,可能需要积极的治疗策略。
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Prognostic value of right ventricular dysfunction in patients with acute pulmonary embolism and normal blood pressure

Introduction

The role of echocardiographic right ventricular (RV) dysfunction in predicting clinical outcome in clinically stable patients with pulmonary embolism (PE) is undefined. In this study, we assessed the prevalence and clinical outcome of normotensive patients with RV dysfunction among a broad spectrum of PE patients.

Method

This retrospective clinical outcome study included cohort of 186 consecutive patients (age: 62 ± 15 years) with documented PE. Acute RV dysfunction was diagnosed in the presence of one or more of the following criteria: a quotient of RV septal-lateral diameter/LV septal-lateral diameter > 0.9 in the 4 chamber view in TTE or CT, RV hypokinesis (TAPSE < 15 mm), Doppler evidence of pulmonary hypertension (PASP > 40 mmHg) and/or paradox septal systolic motion.

Results

Eighty-eight patients were judged to have RV dysfunction (47.3%). There was no difference in age, gender, prevalence of deep venous thrombosis (DVT), cancer or other risk factors in these two groups. In hospital mortality (21.6% vs. 5.4%; P = 0.001), cardiogenic shock (P = 0.001), and thrombolytic therapy use (P = 0.004) were significantly higher for RV dysfunction patients than for the other group. The multivariate logistic regression models revealed significant associations between RV dysfunction and in-hospital mortality (OR: 3.815, 95% CI: 1.012–10.47, P = 0.001)

Conclusion

A significant proportion (47%) of normotensive patients with acute PE presents with RV dysfunction; these patients with latent hemodynamic impairment have more PE-related shock and in-hospital mortality and may require aggressive therapeutic strategies.

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来源期刊
Archives of Cardiovascular Diseases Supplements
Archives of Cardiovascular Diseases Supplements CARDIAC & CARDIOVASCULAR SYSTEMS-
自引率
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发文量
508
期刊介绍: Archives of Cardiovascular Diseases Supplements is the official journal of the French Society of Cardiology. The journal publishes original peer-reviewed clinical and research articles, epidemiological studies, new methodological clinical approaches, review articles, editorials, and Images in cardiovascular medicine. The topics covered include coronary artery and valve diseases, interventional and pediatric cardiology, cardiovascular surgery, cardiomyopathy and heart failure, arrhythmias and stimulation, cardiovascular imaging, vascular medicine and hypertension, epidemiology and risk factors, and large multicenter studies. Additionally, Archives of Cardiovascular Diseases also publishes abstracts of papers presented at the annual sessions of the Journées Européennes de la Société Française de Cardiologie and the guidelines edited by the French Society of Cardiology.
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