Lamotrigine as an alternative treatment for paroxysmal kinesigenic dyskinesia

Brief episodes of involuntary movement triggered by purposeful actions are characteristic of paroxysmal kinesigenic dyskinesia (PKD) and can interfere with daily life.¹ Carbamazepine and oxcarbazepine are effective at reducing episodes but have teratogenic risks that limit their therapeutic potential.² There is limited information describing alternate sodium channel blockers as first-line therapies for PKD, and specifically there is no recommendation for the use of alternative agents for females of childbearing potential. We conducted an institutional retrospective chart review of patients with PKD seen between 2013 and 2022. Our research ethics board approved the identification of participants by diagnostic code in the electronic medical records and waived the requirement for written informed consent.

Both patients reported complete resolution of their events on lamotrigine with recurrence only with missed doses.

We propose lamotrigine as a preferred agent in females of childbearing potential. Pharmacological management of PKD is indicated for frequent, intolerable episodes that interfere with daily life. There are no clinical trials for PKD, so physicians must rely on Class IV evidence to guide management. The literature supports the use of carbamazepine and oxcarbazepine as equivalent first-line agents in the management of PKD.^{1, 3-5}

Lamotrigine has been suggested as a second-line agent for PKD with few reports of use as a first-line agent.^6-8 The largest cohort reported 100% attack-free rate after four weeks of lamotrigine in 18 pre-pubescent children.⁶ Of particular importance is the evidence that carbamazepine and oxcarbazepine can cause rare but significant fetal malformations when used in females of childbearing age, whereas lamotrigine has the lowest risk of fetal malformation.² A recent meta-analysis found a statistically significant increase in major congenital malformations with carbamazepine monotherapy (odds ratio [OR] 1.37) and oxcarbazepine (OR 1.32 *not statistically significant) compared to lamotrigine (OR 0.96).²

The need for an alternative agent in this population is not adequately addressed in the literature. Our experience suggests that lamotrigine is an effective agent in adolescent post-pubertal patients and may be a safe and effective option for females of childbearing potential. Further studies with larger cohorts will be required to investigate lamotrigine's efficacy and tolerability as a first-line agent for PKD and to better understand the effect of pregnancy on PKD and on lamotrigine therapy.

Heather Leduc-Pessah: Conceptualization (supporting); methodology (lead); data curation (lead); writing—original draft (lead); writing—review and editing (equal). Asif Doja: Conceptualization (lead); methodology (supporting); writing—review and editing (equal); supervision (lead).

The authors declare no conflicts of interest.