Application and perspectives of organoids in pancreatic cancer research

For many years, the research on human pancreatic cancer has been based on the traditional two-dimensional metabolism model or genetic engineering mouse model. But these models can not accurately reflect the characteristics of pancreatic cancer and the status of pancreatic cancer microenvironment. As a novel three-dimensional culture technique in vitro, organoid has established reliable in vitro tumor models for pancreatic cancer, liver cancer, gastrointestinal cancer, colon adenocarcinoma, Barrett esophagus and many other diseases. It opens up a new horizon for studying the biological characteristics of pancreatic cancer, exploring more specific anti-pancreatic drugs and formulating individualized treatment schemes for pancreatic cancer. In this paper, the application of organoid technology in pancreatic cancer related research is analyzed and prospected. Key words: Organoid; Pancreatic cancer; Screening of anti-tumor drugs; Individualized treatment of pancreatic cancer