瘦素(rs779039)和脂联素(rs17300539)的遗传多态性和血浆浓度与儿童和青少年肥胖有关

IF 1.4 Q3 PEDIATRICS Revista Paulista De Pediatria Pub Date : 2022-06-10 DOI:10.1590/1984-0462/2022/40/2021030IN
C. Menezes, Eduardo Rodrigues Alves Junior, G. N. O. Costa, T. Dombroski, R. T. Mattos, J. A. Gomes, F. Rios-Santos
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引用次数: 0

摘要

摘要目的:本研究的目的是比较富营养化和肥胖儿童和青少年的人体测量学、生化和激素特征以及瘦素、脂联素和肿瘤坏死因子α (TNF-α)遗传多态性的存在。方法:这是一项涉及104名儿童和青少年的病例对照研究。评估所有受试者的人体测量特征、临床、实验室和遗传多态性参数。样本根据美国疾病控制与预防中心(CDC)的分类从专门治疗儿童和青少年肥胖的儿科内分泌科门诊选取,对照组则从同一地点的普通儿科门诊选取。结果:发现黑肤色、父母肥胖、父母高血压、过早断奶等参数与肥胖有关。研究发现,胰岛素、甘油三酯、总胆固醇、低密度脂蛋白胆固醇、CRP-U、AST、ALT、GGT、游离T4、IGF-1和尿酸水平的升高以及高密度脂蛋白胆固醇水平的降低与肥胖的高几率有关。瘦素中AG/AA多态性的存在与肥胖几率增加290% (OR 3.9)相关,脂联素基因的几率增加740% (OR 8.4)。在这些患有AG/AA单倍型的肥胖儿童和青少年中,富营养化个体的血清瘦素水平升高,脂联素水平降低,而血清TNF-α水平没有变化。结论:瘦素和脂联素基因的AG/AA多态性改变了这些脂肪因子的血清水平,使他们易患肥胖,许多人体测量学、生化和激素标志物也发生了改变,显示了这些肥胖儿童和青少年健康的早期后果。
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Genetic polymorphisms and plasma concentrations of leptin (rs7799039) and adiponectin (rs17300539) are associated with obesity in children and adolescents
ABSTRACT Objective: The aim of this study was to compare the anthropometric, biochemical, and hormonal characteristics and the presence of genetic polymorphisms of leptin, adiponectin, and tumor necrosis factor alpha (TNF-α) between eutrophic and obese children and adolescents. Methods: This is a case–control study involving 104 children and adolescents. All subjects were assessed for anthropometric characteristics and clinical, laboratory, and genetic polymorphism parameters. The sample was selected from the pediatric endocrinology outpatient clinic specialized in the treatment of obesity in children and adolescents according to the Centers for Disease Control and Prevention (CDC) classification, and controls were selected from the same location in the general pediatric outpatient clinic. Results: As a result, the parameters, such as black color, obese parents, hypertensive parents, and early weaning, were found to be associated with obesity. Increased levels of insulin, triglyceride, total cholesterol, LDL cholesterol, CRP-U, AST, ALT, GGT, free T4, IGF-1, and uric acid and low levels of HDL cholesterol are found to be associated with a higher chance of obesity. The presence of AG/AA polymorphisms in the leptin is associated with a 290% (OR 3.9) higher chance of obesity, and for adiponectin genes, the chances are 740% (OR 8.4) higher. In these obese children and adolescents with AG/AA haplotypes, serum leptin levels were increased and adiponectin levels were decreased in eutrophic individuals, whereas serum TNF-α levels did not change. Conclusions: The AG/AA polymorphisms in the leptin and adiponectin genes alter the serum levels of these adipokines and predispose them to obesity, and many anthropometric, biochemical, and hormonal markers are altered, demonstrating early consequences for the health of these obese children and adolescents.
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来源期刊
Revista Paulista De Pediatria
Revista Paulista De Pediatria Medicine-Pediatrics, Perinatology and Child Health
CiteScore
2.30
自引率
0.00%
发文量
100
审稿时长
11 weeks
期刊介绍: The Revista Paulista de Pediatria publishes original contributions, case reports and review of clinical research with methodological approach in the areas of health and disease of neonates, infants, children and adolescents. The objective is to disseminate research with methodological quality on issues that comprise the health of children and adolescents. All articles are freely available online, via SciELO. Its abbreviated title is Rev. Paul. Pediatr., which should be used in bibliographies, footnotes and bibliographical references and strips.
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