Clare McCormick-Baw M.D., Ph.D. , Morgan Pence Ph.D., D(ABMM) , Laura Filkins Ph.D., D(ABMM)
{"title":"自由生活的阿米巴感染与诊断病例综述","authors":"Clare McCormick-Baw M.D., Ph.D. , Morgan Pence Ph.D., D(ABMM) , Laura Filkins Ph.D., D(ABMM)","doi":"10.1016/j.clinmicnews.2023.07.001","DOIUrl":null,"url":null,"abstract":"<div><p><em>Naegleria fowleri, Balamuthia mandrillaris</em>, and <em>Acanthamoeba</em> species are free-living amebae that are ubiquitously found in soil and water and can opportunistically cause invasive, deadly infections in humans. In this review, we present four patient cases due to free-living amebae and review the epidemiology and clinical significance of the diseases they cause. Specifically, primary amebic encephalitis due to <em>N. fowleri</em>, granulomatous amebic encephalitis due to <em>B. mandrillaris</em> and <em>Acanthamoeba</em> spp., keratitis due to <em>Acanthamoeba</em> spp., and non-central nervous system systemic infections (due to <em>B. mandrillaris</em> and <em>Acanthamoeba</em> spp.) are reviewed, and the clinical utility of microbiologic and histopathologic methods for diagnosing infections due to free-living amebae are compared.</p></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":"45 13","pages":"Pages 101-113"},"PeriodicalIF":0.0000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Case-Based Review of Free-living Amebic Human Infections and Diagnosis\",\"authors\":\"Clare McCormick-Baw M.D., Ph.D. , Morgan Pence Ph.D., D(ABMM) , Laura Filkins Ph.D., D(ABMM)\",\"doi\":\"10.1016/j.clinmicnews.2023.07.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><em>Naegleria fowleri, Balamuthia mandrillaris</em>, and <em>Acanthamoeba</em> species are free-living amebae that are ubiquitously found in soil and water and can opportunistically cause invasive, deadly infections in humans. In this review, we present four patient cases due to free-living amebae and review the epidemiology and clinical significance of the diseases they cause. Specifically, primary amebic encephalitis due to <em>N. fowleri</em>, granulomatous amebic encephalitis due to <em>B. mandrillaris</em> and <em>Acanthamoeba</em> spp., keratitis due to <em>Acanthamoeba</em> spp., and non-central nervous system systemic infections (due to <em>B. mandrillaris</em> and <em>Acanthamoeba</em> spp.) are reviewed, and the clinical utility of microbiologic and histopathologic methods for diagnosing infections due to free-living amebae are compared.</p></div>\",\"PeriodicalId\":39211,\"journal\":{\"name\":\"Clinical Microbiology Newsletter\",\"volume\":\"45 13\",\"pages\":\"Pages 101-113\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Microbiology Newsletter\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S019643992300034X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Microbiology Newsletter","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S019643992300034X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
A Case-Based Review of Free-living Amebic Human Infections and Diagnosis
Naegleria fowleri, Balamuthia mandrillaris, and Acanthamoeba species are free-living amebae that are ubiquitously found in soil and water and can opportunistically cause invasive, deadly infections in humans. In this review, we present four patient cases due to free-living amebae and review the epidemiology and clinical significance of the diseases they cause. Specifically, primary amebic encephalitis due to N. fowleri, granulomatous amebic encephalitis due to B. mandrillaris and Acanthamoeba spp., keratitis due to Acanthamoeba spp., and non-central nervous system systemic infections (due to B. mandrillaris and Acanthamoeba spp.) are reviewed, and the clinical utility of microbiologic and histopathologic methods for diagnosing infections due to free-living amebae are compared.
期刊介绍：
Highly respected for its ability to keep pace with advances in this fast moving field, Clinical Microbiology Newsletter has quickly become a “benchmark” for anyone in the lab. Twice a month the newsletter reports on changes that affect your work, ranging from articles on new diagnostic techniques, to surveys of how readers handle blood cultures, to editorials questioning common procedures and suggesting new ones.
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