{"title":"SGK3在生理条件下以及在前列腺和乳腺癌症中的激活机制和关键作用。","authors":"Rajesh Basnet","doi":"10.2174/1574362415666200203122829","DOIUrl":null,"url":null,"abstract":"\n\nThe serum and glucocorticoid inducible protein kinase (SGK) family signals downstream of phosphoinositide-3-kinase (PI3K) and is made up of three isoforms: SGK1, 2, and 3. respectively, and their activity is dependent on growth factor activation. Among these SGK family one such potential target and less explored enzyme is SGK3. SGK3 regulate a range of basic cellular processes, such as cell proliferation, migration and survival. Thus play an important role in cancer development. These kinase-signaling pathways present both opportunities and challenges for cancer therapy. In this paper, we reviewed the status of SGK3 regulation and its role in normal cell physiology and transformation. In addition, the potential roles of SGK3 signal transduction in breast cancer and prostate cancer are discussed.\n","PeriodicalId":10868,"journal":{"name":"Current Signal Transduction Therapy","volume":"15 1","pages":"1-7"},"PeriodicalIF":0.0000,"publicationDate":"2020-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1574362415666200203122829","citationCount":"0","resultStr":"{\"title\":\"Mechanisms of activation and key roles of SGK3 under physiological conditions and in prostate and breast cancer.\",\"authors\":\"Rajesh Basnet\",\"doi\":\"10.2174/1574362415666200203122829\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\\n\\nThe serum and glucocorticoid inducible protein kinase (SGK) family signals downstream of phosphoinositide-3-kinase (PI3K) and is made up of three isoforms: SGK1, 2, and 3. respectively, and their activity is dependent on growth factor activation. Among these SGK family one such potential target and less explored enzyme is SGK3. SGK3 regulate a range of basic cellular processes, such as cell proliferation, migration and survival. Thus play an important role in cancer development. These kinase-signaling pathways present both opportunities and challenges for cancer therapy. In this paper, we reviewed the status of SGK3 regulation and its role in normal cell physiology and transformation. In addition, the potential roles of SGK3 signal transduction in breast cancer and prostate cancer are discussed.\\n\",\"PeriodicalId\":10868,\"journal\":{\"name\":\"Current Signal Transduction Therapy\",\"volume\":\"15 1\",\"pages\":\"1-7\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-02-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.2174/1574362415666200203122829\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Signal Transduction Therapy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1574362415666200203122829\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Signal Transduction Therapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1574362415666200203122829","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
Mechanisms of activation and key roles of SGK3 under physiological conditions and in prostate and breast cancer.
The serum and glucocorticoid inducible protein kinase (SGK) family signals downstream of phosphoinositide-3-kinase (PI3K) and is made up of three isoforms: SGK1, 2, and 3. respectively, and their activity is dependent on growth factor activation. Among these SGK family one such potential target and less explored enzyme is SGK3. SGK3 regulate a range of basic cellular processes, such as cell proliferation, migration and survival. Thus play an important role in cancer development. These kinase-signaling pathways present both opportunities and challenges for cancer therapy. In this paper, we reviewed the status of SGK3 regulation and its role in normal cell physiology and transformation. In addition, the potential roles of SGK3 signal transduction in breast cancer and prostate cancer are discussed.
期刊介绍：
In recent years a breakthrough has occurred in our understanding of the molecular pathomechanisms of human diseases whereby most of our diseases are related to intra and intercellular communication disorders. The concept of signal transduction therapy has got into the front line of modern drug research, and a multidisciplinary approach is being used to identify and treat signaling disorders.
The journal publishes timely in-depth reviews, research article and drug clinical trial studies in the field of signal transduction therapy. Thematic issues are also published to cover selected areas of signal transduction therapy. Coverage of the field includes genomics, proteomics, medicinal chemistry and the relevant diseases involved in signaling e.g. cancer, neurodegenerative and inflammatory diseases. Current Signal Transduction Therapy is an essential journal for all involved in drug design and discovery.
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