{"title":"药物开发过程中评估血液毒性的微生理系统","authors":"Eva-Maria Dehne, Annika Winter, Uwe Marx","doi":"10.1016/j.cotox.2019.09.008","DOIUrl":null,"url":null,"abstract":"<div><p><span>Microphysiological systems are progressively entering the pharmaceutical industry, and various systems have already proven to be highly valuable at different stages of the drug development<span> process. The field of hematotoxicity research has so far received only minor attention, even though microphysiological systems might provide key benefits over current assays. In this review, we will highlight the need for more complex human </span></span><em>in vitro</em> assays, and how emerging technologies such as microphysiological systems present novel solutions for the study of adverse hematologic effects.</p></div>","PeriodicalId":93968,"journal":{"name":"Current opinion in toxicology","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cotox.2019.09.008","citationCount":"4","resultStr":"{\"title\":\"Microphysiological systems in the evaluation of hematotoxicities during drug development\",\"authors\":\"Eva-Maria Dehne, Annika Winter, Uwe Marx\",\"doi\":\"10.1016/j.cotox.2019.09.008\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>Microphysiological systems are progressively entering the pharmaceutical industry, and various systems have already proven to be highly valuable at different stages of the drug development<span> process. The field of hematotoxicity research has so far received only minor attention, even though microphysiological systems might provide key benefits over current assays. In this review, we will highlight the need for more complex human </span></span><em>in vitro</em> assays, and how emerging technologies such as microphysiological systems present novel solutions for the study of adverse hematologic effects.</p></div>\",\"PeriodicalId\":93968,\"journal\":{\"name\":\"Current opinion in toxicology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2019-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.cotox.2019.09.008\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current opinion in toxicology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2468202019300014\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current opinion in toxicology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468202019300014","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Microphysiological systems in the evaluation of hematotoxicities during drug development
Microphysiological systems are progressively entering the pharmaceutical industry, and various systems have already proven to be highly valuable at different stages of the drug development process. The field of hematotoxicity research has so far received only minor attention, even though microphysiological systems might provide key benefits over current assays. In this review, we will highlight the need for more complex human in vitro assays, and how emerging technologies such as microphysiological systems present novel solutions for the study of adverse hematologic effects.
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