Effect of chronic restraint stress on body weight of male Sprague Dawley rats

Background:  Stress disturbs body weight and food intake, but the core mechanisms are not well understood.    Study design:  Experimental     Materials and Methods:  The study was conducted in  National  Institute  of  Health  (NIH),  Islamabad Sixty male Sprague Dawley rats (mean wt 250 ± 50 grams) were used and divided into 2 groups.   Each group comprised of 30 rats.   Group I was taken as control. Group II was exposed to chronic stress.  Results:  The comparison of weight gain by the different groups disclosed that there was a significant decrease in weight gain of rats exposed to the chronic stress as compared to control group.     Conclusion:  Chronic restraint stress has a detrimental effect on body weight.