75年期间氧化状态和硫醇/二硫化物稳态的变化 g五小时内的口服葡萄糖耐量测试

IF 2.1 4区 医学 Q2 SURGERY Journal of Investigative Surgery Pub Date : 2022-06-01 DOI:10.1080/08941939.2022.2084189
Z. K. Kıraz, Ezgi Kar, F. Kar, E. Kocatürk, M. Kebapçı, İ. Ö. Alatas, S. Uslu
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引用次数: 2

摘要

背景口服葡萄糖负荷可能影响口服葡萄糖耐量试验(OGTT)中的氧化状态。我们的目的是研究氧化和抗氧化标志物和硫醇/二硫参数在OGTT过程中的变化。方法对42例有2型糖尿病危险的志愿者进行OGTT,根据OGTT期间血糖水平分为血糖正常组、糖尿病前期组和糖尿病组。葡萄糖、胰岛素、c肽、总抗氧化状态(TAS)、总氧化状态(TOS)、总硫醇和天然硫醇用自动分析仪测定5小时。结果TAS降低,TOS升高始于葡萄糖和胰岛素水平升高。TAS在第3小时开始增加,第5小时达到最高水平。在血糖正常和糖尿病组中,第4小时的OSI水平高于空腹和第1小时。糖尿病前期组TAS明显高于其他各组,TOS峰值出现在第2 h (p < 0.05)。天然硫醇和总硫醇水平在OGTT过程中呈变化过程,在过程结束时两者均升高(p < 0.05)。二硫化物水平呈上升趋势,但在血糖正常组和糖尿病组中无统计学差异。前驱糖尿病组第2小时二硫化物水平低于空腹,第3、4、5小时二硫化物水平显著升高,第5小时二硫化物水平也高于空腹。结论各组小鼠在葡萄糖负荷后5h内氧化应激参数和硫醇/二硫平衡均出现恶化。这些结果表明氧化应激在OGTT过程中发生。
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Oxidative Status and Thiol/Disulfide Homeostasis Are Changed During 75 g Oral Glucose Tolerance Test over a Five-Hour Period
Abstract Background Oral glucose loading may affect oxidative status during oral glucose tolerance test (OGTT). We aimed to investigate how oxidant and antioxidant markers and thiol/disulfide parameters change during OGTT. Methods OGTT was performed to 42 volunteers who were considered risk of type 2 diabetes and were divided into three groups (normoglycemic, prediabetes, diabetes) according glucose levels during OGTT. Glucose, insulin, c-peptide, total antioxidant status (TAS), total oxidant status (TOS), total thiol and native thiol were investigated with auto-anaylzer for five-hours period. Results Decrease of TAS and increase of TOS levels began with the increase in glucose and insulin levels. The increase of TAS started at third hour and reached the highest levels at fifth hour. OSI levels were higher at fourth hour than fasting and first hours in normoglycemic and diabetes groups. In the prediabetic group, TAS were higher than the other groups, TOS peak was at the second hour (p < 0.05). Native thiol and total thiol levels showed variable course during OGTT, both parameters increased at the end of the process (p < 0.05). Disulfide levels showed an increase trend but it was not statistically different in normoglycemic and diabetes groups. In prediabetes group, second hour disulfide level was lower than fasting state and disulfide was significantly increased at third, fourth and fifth hours and fifth hour disulfide level was also higher than fasting. Conclusion Oxidative stress parameters and thiol/disulfide balance were found to deteriorate within five-hours after glucose loading in all groups. These results indicates that oxidative stress occurs during OGTT.
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来源期刊
CiteScore
4.20
自引率
0.00%
发文量
114
审稿时长
6-12 weeks
期刊介绍: Journal of Investigative Surgery publishes peer-reviewed scientific articles for the advancement of surgery, to the ultimate benefit of patient care and rehabilitation. It is the only journal that encompasses the individual and collaborative efforts of scientists in human and veterinary medicine, dentistry, basic and applied sciences, engineering, and law and ethics. The journal is dedicated to the publication of outstanding articles of interest to the surgical research community.
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