儿童非霍奇金淋巴瘤:病理方面和诊断挑战

IF 1.9 Q3 PATHOLOGY Clinical Pathology Pub Date : 2022-01-01 DOI:10.1177/2632010X221090156
S. Derqaoui, I. Boujida, Oussama Marbouh, L. Rouas, L. Hessissen, N. Lamalmi
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引用次数: 2

摘要

非霍奇金淋巴瘤是儿童常见的恶性肿瘤。在发展中国家,关于儿童NHL的临床病理方面的现有数据有限,由于缺乏分子研究,诊断方法显得更加微妙。我们研究的目的是:分析儿童NHL的病理谱,并强调诊断中的挑战,包括:有限的生物材料;不常见的亚密码、年龄组或本地化。我们回顾性分析了在4年的时间里,在儿科病理科诊断的101例儿童NHL的临床病理特征 男78例(77.2%),女23例(22.8%)。中位年龄为7.2岁 年。NHL最常见的组织学亚型为伯基特淋巴瘤65例(64.4%);其次是淋巴母细胞淋巴瘤22例、大B细胞淋巴瘤9例(8.9%);间变性T细胞淋巴瘤3例;NOS成熟T细胞淋巴瘤和儿童型滤泡性淋巴瘤各1例。总之,摩洛哥的这项研究阐明了NHL的分布模式,并强调了诊断这些肿瘤的挑战。
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Non Hodgkin Lymphoma Among Children: Pathological Aspects and Diagnostic Challenges
Non-Hodgkin lymphoma (NHL) are common malignancies in children. Available data on clinico-pathological aspects of pediatric NHL in developping countries are limited and diagnostic approach appears more delicate with absence of molecular studies. The objectives of our study are: analyzing the pathological spectrum of NHL among children and highlighting challenges in the diagnosis including: limited biopsic material; unususal subtyptes, age group, or localization. We retrospectively analyzed clinico pathological characteristics of 101 NHL’s cases among children diagnosed in the Pediatric’s pathology unit over a period of 4 years There were 78 (77.2%) male and 23 (22.8%) female. The median age was 7.2 years. The most common histologic subtypes of NHL were Burkitt lymphoma in 65 patients (64.4% ); followed by lymphoblastic lymphoma in 22 patients, large B-cell lymphoma in 9 patients ( 8.9%); anaplastic T cell lymphoma in 3 patients; NOS mature T cell lymphoma and pediatric type follicular lympoma in 1 patient each. In conclusion, this study Morocco illustrates the pattern of distribution of NHL and emphasizes challenges in the diagnosis of these neoplasms.
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来源期刊
Clinical Pathology
Clinical Pathology PATHOLOGY-
CiteScore
2.20
自引率
7.70%
发文量
66
期刊最新文献
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