生物医学用坚韧多孔聚乙烯醇/POC膜的制备与表征

IF 1.6 Q4 ENGINEERING, BIOMEDICAL Biosurface and Biotribology Pub Date : 2022-10-20 DOI:10.1049/bsb2.12053
Zuoliang Niu, Ziying You, William W. Lu, Zhenming Wang, Chenglin Wang
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引用次数: 0

摘要

聚乙烯醇(PVA)是一种合成聚合物,已被广泛研究用于通过静电纺丝制造多孔膜,用于各种生物医学应用。然而,静电纺聚乙烯醇纳米纤维膜力学性能差,严重限制了其在生物医学领域的应用。为此,通过在PVA纤维膜中引入聚(1,8-辛二醇柠檬酸酯)(POC),再经柠檬酸钠处理,制备了多孔、坚韧的PVA基杂化纤维膜。柠檬酸钠处理后的PVA/POC (CPP)膜的拉伸模量、断裂强度和断裂韧性分别达到119.81±5.32 MPa、10.34±1.57 MPa和401.51±11.67 MJ m−2,分别是原始PVA膜的~ 60、~ 10和~ 4倍。此外,新型CPP膜具有合适的生物降解率和高细胞/组织亲和力,表明其在软硬组织修复方面具有潜在的生物医学应用前景。该策略具有多孔结构、高机械性能和优异的生物相容性,为开发先进的生物材料提供了一种简单而有效的方法。
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Preparation and characterisation of tough and porous polyvinyl alcohol/POC membrane for biomedical applications

Polyvinyl alcohol (PVA) is a synthetic polymer that has been extensively studied for fabricating porous membranes via electrospinning for diverse biomedical applications. However, the poor mechanical properties of electrostatically spun PVA nanofiber membranes severely limit their application in the biomedical field. Therefore, porous, tough hybrid PVA-based fibrous membranes were prepared by introducing poly (1,8-octanediol citrate) (POC) into PVA fibrous membranes followed by sodium citrate treatment. The tensile modulus, fracture strength, and fracture toughness of the sodium citrate-treated PVA/POC (CPP) membranes achieve 119.81 ± 5.32 MPa, 10.34 ± 1.57 MPa and 401.51 ± 11.67 MJ m−2, respectively, which were ∼60, ∼10, and ∼4 times higher than those achieved by the pristine PVA membrane. Moreover, the novel CPP membranes exhibited suitable biodegradation ratios and high cell/issue affinities, suggesting their potential biomedical applications in soft or hard tissue repair. This strategy, which provides porous structures, high mechanical properties and excellent biocompatibility, demonstrates a facile but effective approach for the development of advanced biomaterials.

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来源期刊
Biosurface and Biotribology
Biosurface and Biotribology Engineering-Mechanical Engineering
CiteScore
1.70
自引率
0.00%
发文量
27
审稿时长
11 weeks
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