明胶粘结剂对姜黄浸膏片剂配方的影响

Adidiya Permadi, Iis Wahyuningsih, S. Yuliani, Ibdal Satar, Ratna Wijayatri
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引用次数: 1

摘要

片剂配方的主要成分是填料、粘合剂、破碎机、稀释剂和润滑剂。在这些成分中,粘合剂在片剂颗粒形成过程中对粉末的内聚性能起着关键作用。在这项研究中,使用15克姜黄提取物、35克气雾剂、12.8克乳糖、1%硬脂酸镁、200毫升水解物和明胶作为粘合剂配制姜黄提取物片剂。为了评估明胶对片剂制剂的影响,然后以不同的制剂制备明胶,即分别为0.1g(制剂A)、0.2g(制剂B)和0.5g(制剂C)。基于片剂性能,配方C的姜黄片剂满足脆性小于1%、硬度在4-8kg范围内和崩解时间在15分钟以下的标准要求。
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EFFECT OF GELATIN AS A BINDER ON TURMERIC EXTRACT TABLET FORMULATION
The main components for tablet formulations are the fillers, binders, crushers, thinners and lubricants. Among these components, the binders play a key role on the powder cohesion properties during the formation of tablet granules. In this study, turmeric extract tablets were formulated using 15 g of turmeric extract, 35 g of aerosil, 12.8 g of lactose, 1% magnesium stearate, 200 ml of aquadest and gelatin as a binder. To evaluate the effect of gelatin on the tablet formulation, the gelatin was then prepared in different formulation namely 0.1 g (formulation A), 0.2 g (formulation B) and 0.5 g (formulation C), respectivley. Based on the tablet properties, the turmeric tablet with formulation C met the standard requirements of friability less than 1%, the hardness in the range of 4 -8 kg and disintegration time under 15 minutes.
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自引率
0.00%
发文量
70
审稿时长
12 weeks
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