{"title":"白细胞介素22基因多态性与乙型肝炎病毒相关急性-慢性肝衰竭预后的关系","authors":"Su Lin, Qing-hui Zhou, Yehong Lin, Mingfang Wang","doi":"10.3760/CMA.J.ISSN.1000-6680.2018.12.003","DOIUrl":null,"url":null,"abstract":"Objective \nTo investigate the association between interleukin-22 (IL-22) single nucleotide polymorphisms (SNPs) and the prognosis of hepatitis B virus related acute-on-chronic liver failure (HBV-ACLF). \n \n \nMethods \nThe patients with HBV-ACLF from the First Affiliated Hospital of Fujian Medical University were retrospectively studied. Seven SNP genotypes of IL-22 gene, including rs2227478, rs2227491, rs1179251, rs1179249, rs2227473, rs2227484, and rs11611206, were detected using imLDR™ multiple SNP typing kit and the distribution features of SNP genotypes were described. The relationship between the distribution of SNP genotypes and alleles and the prognosis of ACLF was analyzed. Comparison of genotypes and allele frequencies between groups were performed by chi-square test of R×C table or Fisher's exact tests. Binary logistic regression analysis was used to analyze whether IL-22 gene polymorphisms was an independent prognostic factor for patients with ACLF. \n \n \nResults \nA total of 122 patients with HBV-ACLF were included in this study. Ninety-two (75.1%) were male and 30 (24.59%) were female. Patients were stratified as survival group (90 cases) and non-survival group (32 cases) according to the Results of three months follow-up. The genotype distribution of rs2227484 of IL-22 gene was significantly different between the two groups (χ2=6.128, P=0.033). The A allele frequency in the non-survival group (15.6%) was significantly higher than that in the survival group (5.6%) with statistically significance (OR=0.318, 95% CI=0.126-0.804, P=0.012). There was no significant difference in the other six SNP genotypes of IL-22 gene between the two groups (all P >0.05). However, binary logistic regression showed that rs2227484 of IL-22 gene was not an independent risk factor for the short-term mortality in HBV-ACLF patients (adjusted OR=3.102, 95%CI: 0.939-10.250, P=0.063). \n \n \nConclusions \nThe A allele and AA genotype of rs2227484 of IL-22 gene may be associated with a short-term prognosis in patients with HBV-ACLF. \n \n \nKey words: \nHepatitis B virus; Polymorphism, genetic; Interleukin-22; Acute-on-chronic liver failure","PeriodicalId":10127,"journal":{"name":"中华传染病杂志","volume":"36 1","pages":"730-735"},"PeriodicalIF":0.0000,"publicationDate":"2018-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association between interleukin-22 genetic polymorphisms and the prognosis of hepatitis B virus related acute-on-chronic liver failure\",\"authors\":\"Su Lin, Qing-hui Zhou, Yehong Lin, Mingfang Wang\",\"doi\":\"10.3760/CMA.J.ISSN.1000-6680.2018.12.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective \\nTo investigate the association between interleukin-22 (IL-22) single nucleotide polymorphisms (SNPs) and the prognosis of hepatitis B virus related acute-on-chronic liver failure (HBV-ACLF). \\n \\n \\nMethods \\nThe patients with HBV-ACLF from the First Affiliated Hospital of Fujian Medical University were retrospectively studied. Seven SNP genotypes of IL-22 gene, including rs2227478, rs2227491, rs1179251, rs1179249, rs2227473, rs2227484, and rs11611206, were detected using imLDR™ multiple SNP typing kit and the distribution features of SNP genotypes were described. The relationship between the distribution of SNP genotypes and alleles and the prognosis of ACLF was analyzed. Comparison of genotypes and allele frequencies between groups were performed by chi-square test of R×C table or Fisher's exact tests. Binary logistic regression analysis was used to analyze whether IL-22 gene polymorphisms was an independent prognostic factor for patients with ACLF. \\n \\n \\nResults \\nA total of 122 patients with HBV-ACLF were included in this study. Ninety-two (75.1%) were male and 30 (24.59%) were female. Patients were stratified as survival group (90 cases) and non-survival group (32 cases) according to the Results of three months follow-up. The genotype distribution of rs2227484 of IL-22 gene was significantly different between the two groups (χ2=6.128, P=0.033). The A allele frequency in the non-survival group (15.6%) was significantly higher than that in the survival group (5.6%) with statistically significance (OR=0.318, 95% CI=0.126-0.804, P=0.012). There was no significant difference in the other six SNP genotypes of IL-22 gene between the two groups (all P >0.05). However, binary logistic regression showed that rs2227484 of IL-22 gene was not an independent risk factor for the short-term mortality in HBV-ACLF patients (adjusted OR=3.102, 95%CI: 0.939-10.250, P=0.063). \\n \\n \\nConclusions \\nThe A allele and AA genotype of rs2227484 of IL-22 gene may be associated with a short-term prognosis in patients with HBV-ACLF. \\n \\n \\nKey words: \\nHepatitis B virus; Polymorphism, genetic; Interleukin-22; Acute-on-chronic liver failure\",\"PeriodicalId\":10127,\"journal\":{\"name\":\"中华传染病杂志\",\"volume\":\"36 1\",\"pages\":\"730-735\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-12-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"中华传染病杂志\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.1000-6680.2018.12.003\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华传染病杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1000-6680.2018.12.003","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Association between interleukin-22 genetic polymorphisms and the prognosis of hepatitis B virus related acute-on-chronic liver failure
Objective
To investigate the association between interleukin-22 (IL-22) single nucleotide polymorphisms (SNPs) and the prognosis of hepatitis B virus related acute-on-chronic liver failure (HBV-ACLF).
Methods
The patients with HBV-ACLF from the First Affiliated Hospital of Fujian Medical University were retrospectively studied. Seven SNP genotypes of IL-22 gene, including rs2227478, rs2227491, rs1179251, rs1179249, rs2227473, rs2227484, and rs11611206, were detected using imLDR™ multiple SNP typing kit and the distribution features of SNP genotypes were described. The relationship between the distribution of SNP genotypes and alleles and the prognosis of ACLF was analyzed. Comparison of genotypes and allele frequencies between groups were performed by chi-square test of R×C table or Fisher's exact tests. Binary logistic regression analysis was used to analyze whether IL-22 gene polymorphisms was an independent prognostic factor for patients with ACLF.
Results
A total of 122 patients with HBV-ACLF were included in this study. Ninety-two (75.1%) were male and 30 (24.59%) were female. Patients were stratified as survival group (90 cases) and non-survival group (32 cases) according to the Results of three months follow-up. The genotype distribution of rs2227484 of IL-22 gene was significantly different between the two groups (χ2=6.128, P=0.033). The A allele frequency in the non-survival group (15.6%) was significantly higher than that in the survival group (5.6%) with statistically significance (OR=0.318, 95% CI=0.126-0.804, P=0.012). There was no significant difference in the other six SNP genotypes of IL-22 gene between the two groups (all P >0.05). However, binary logistic regression showed that rs2227484 of IL-22 gene was not an independent risk factor for the short-term mortality in HBV-ACLF patients (adjusted OR=3.102, 95%CI: 0.939-10.250, P=0.063).
Conclusions
The A allele and AA genotype of rs2227484 of IL-22 gene may be associated with a short-term prognosis in patients with HBV-ACLF.
Key words:
Hepatitis B virus; Polymorphism, genetic; Interleukin-22; Acute-on-chronic liver failure
期刊介绍：
The Chinese Journal of Infectious Diseases was founded in February 1983. It is an academic journal on infectious diseases supervised by the China Association for Science and Technology, sponsored by the Chinese Medical Association, and hosted by the Shanghai Medical Association. The journal targets infectious disease physicians as its main readers, taking into account physicians of other interdisciplinary disciplines, and timely reports on leading scientific research results and clinical diagnosis and treatment experience in the field of infectious diseases, as well as basic theoretical research that has a guiding role in the clinical practice of infectious diseases and is closely integrated with the actual clinical practice of infectious diseases. Columns include reviews (including editor-in-chief reviews), expert lectures, consensus and guidelines (including interpretations), monographs, short monographs, academic debates, epidemic news, international dynamics, case reports, reviews, lectures, meeting minutes, etc.
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