氧化石墨烯交联负载黄芩苷壳聚糖膜及其生物相容性研究

IF 1.6 Q4 ENGINEERING, BIOMEDICAL Biosurface and Biotribology Pub Date : 2023-06-01 DOI:10.1049/bsb2.12059
Yu Zhu, Lu Zhang, Lei Zhou, Xin Li, Yuancong Zhao, Jin Wang
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引用次数: 0

摘要

壳聚糖具有良好的生物相容性、体内生物降解性和一定的生理活性,可作为药物载体稳定和保护药物成分,促进药物吸收,控制药物释放。利用氧化石墨烯(GO)作为交联剂,其层状结构中的官能团可以与壳聚糖分子中的官能团有效相互作用,从而增强壳聚糖分子的力学性能并优化其控释行为。采用溶液混合法制备了不同氧化石墨烯含量的氧化石墨烯/壳聚糖复合膜。复合膜表面没有明显的氧化石墨烯颗粒聚集,在复合膜的横截面上可以观察到层状结构。差热分析(DTA)表明,氧化石墨烯的加入提高了壳聚糖膜的稳定性。负载黄芩苷的氧化石墨烯/壳聚糖也表现出pH依赖的释放行为,在较低的pH条件下,释放量和释放速率增加。此外,生物学评价结果表明,氧化石墨烯/壳聚糖膜具有良好的体外细胞相容性和适当氧化石墨烯浓度下的组织相容性。该研究提供了一种新的ph依赖性药物载体,可能应用于肿瘤和动脉粥样硬化治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Investigation on baicalin-loaded chitosan film crosslinked by graphene oxide and its biocompatibility

Chitosan has good biocompatibility, in vivo biodegradability and certain physiological activity, which can be used as a drug carrier to stabilise and protect drug components, causing the promotion of drug absorption and controlling drug release. Using graphene oxide (GO) as a cross-linking agent, the functional groups in its lamellar structure can interact effectively with the functional groups in chitosan molecules, leading to enhanced mechanical properties and optimize the controlled drug-release behaviour. GO/chitosan composite films were prepared by the solution mixing method with various GO content and exhibit many hydrogen bonds between the GO and chitosan. There were no obviously agglomerated GO particles in the surface of composite films, and the lamellar structure can be observed in the cross section of the composite films. Differential thermal analysis (DTA) indicated that the addition of GO increased the stability of the chitosan film. The baicalin-loaded GO/Chitosan also exhibited pH dependent release behaviour, with an increasing release amount and rate at lower pH medium. In addition, the result of biological evaluations showed that the GO/Chitosan films had good cytocompatibility in vitro and histocompatibility at appropriate GO concentrations. This investigation offered a new pH-dependent drug carrier potentially applied for tumour and atherosclerosis treatment.

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来源期刊
Biosurface and Biotribology
Biosurface and Biotribology Engineering-Mechanical Engineering
CiteScore
1.70
自引率
0.00%
发文量
27
审稿时长
11 weeks
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