{"title":"三叶鼠尾草提取物对大鼠十二指肠平滑肌的解痉作用","authors":"Islam H. AlTarawneh","doi":"10.31901/24566772.2019/13.03.588","DOIUrl":null,"url":null,"abstract":"Salvia triloba is considered one of the medicinal plant that is frequently used in Jordan and the Middle East in alternative medicine against a number of diseases, including gastrointestinal disorders. The effects of Salvia triloba leaf aqueous extracton the isolated smooth muscles of the rat duodenum were investigated. Isolated organ bath was adopted. The specimens were pre-contracted with reagents such as acetylcholine, potassium chloride (KCl), and barium chloride (BaCl2). .Then Salvia triloba extract was added in concentrations of 0.1–3mg/ml. The contraction-inhibition signals were collected and the effect was traced and analyzed. The aqueous Salvia triloba leaf extract inhibited the spontaneous contraction of rat duodenum in a dose-dependent manner, especially in the inhibition of acetylcholine. No significant inhibition was noticed with either KCl or BaCl2. The aqueous Salvia triloba leaf extract showed antispasmodic action which took its effect through the inhibition of acetylcholine that explained its use traditionally in alleviating gastrointestinal disorders.","PeriodicalId":39279,"journal":{"name":"Studies on Ethno-Medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Spasmolytic Effects of Salvia triloba Leaf Extract on Smooth Muscles of the Duodenum in Rats\",\"authors\":\"Islam H. AlTarawneh\",\"doi\":\"10.31901/24566772.2019/13.03.588\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Salvia triloba is considered one of the medicinal plant that is frequently used in Jordan and the Middle East in alternative medicine against a number of diseases, including gastrointestinal disorders. The effects of Salvia triloba leaf aqueous extracton the isolated smooth muscles of the rat duodenum were investigated. Isolated organ bath was adopted. The specimens were pre-contracted with reagents such as acetylcholine, potassium chloride (KCl), and barium chloride (BaCl2). .Then Salvia triloba extract was added in concentrations of 0.1–3mg/ml. The contraction-inhibition signals were collected and the effect was traced and analyzed. The aqueous Salvia triloba leaf extract inhibited the spontaneous contraction of rat duodenum in a dose-dependent manner, especially in the inhibition of acetylcholine. No significant inhibition was noticed with either KCl or BaCl2. The aqueous Salvia triloba leaf extract showed antispasmodic action which took its effect through the inhibition of acetylcholine that explained its use traditionally in alleviating gastrointestinal disorders.\",\"PeriodicalId\":39279,\"journal\":{\"name\":\"Studies on Ethno-Medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-04-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Studies on Ethno-Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.31901/24566772.2019/13.03.588\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Social Sciences\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Studies on Ethno-Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31901/24566772.2019/13.03.588","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Social Sciences","Score":null,"Total":0}
Spasmolytic Effects of Salvia triloba Leaf Extract on Smooth Muscles of the Duodenum in Rats
Salvia triloba is considered one of the medicinal plant that is frequently used in Jordan and the Middle East in alternative medicine against a number of diseases, including gastrointestinal disorders. The effects of Salvia triloba leaf aqueous extracton the isolated smooth muscles of the rat duodenum were investigated. Isolated organ bath was adopted. The specimens were pre-contracted with reagents such as acetylcholine, potassium chloride (KCl), and barium chloride (BaCl2). .Then Salvia triloba extract was added in concentrations of 0.1–3mg/ml. The contraction-inhibition signals were collected and the effect was traced and analyzed. The aqueous Salvia triloba leaf extract inhibited the spontaneous contraction of rat duodenum in a dose-dependent manner, especially in the inhibition of acetylcholine. No significant inhibition was noticed with either KCl or BaCl2. The aqueous Salvia triloba leaf extract showed antispasmodic action which took its effect through the inhibition of acetylcholine that explained its use traditionally in alleviating gastrointestinal disorders.
期刊介绍：
Studies on Ethno-Medicine is a peer reviewed, internationally circulated journal. It publishes reports of original research, theoretical articles, timely reviews, brief communications, book reviews and other publications in the interdisciplinary field of ethno-medicine. The journal serves as a forum for physical, social and life scientists as well as for health professionals. The transdisciplinary areas covered by this journal include, but are not limited to, Physical Sciences, Anthropology, Sociology, Geography, Life Sciences, Environmental Sciences, Botany, Agriculture, Home Science, Zoology, Genetics, Biology, Medical Sciences, Public Health, Demography and Epidemiology. The journal publishes basic, applied and methodologically oriented research from all such areas. The journal is committed to prompt review, and priority publication is given to manuscripts with novel or timely findings, and to manuscript of unusual interest. Further, the manuscripts are categorised under three types, namely - Regular articles, Short Communications and Reviews. The researchers are invited to submit original papers in English (papers published elsewhere or under consideration elsewhere shall not be considered).
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