克罗米芬柠檬酸盐刺激周期-额外的促性腺激素刺激增加子宫内膜厚度而不增加植入率

IF 1.7 Q3 OBSTETRICS & GYNECOLOGY Facts Views and Vision in ObGyn Pub Date : 2022-03-01 DOI:10.52054/FVVO.14.1.013
I. Magaton, A. Helmer, M. Roumet, P. Stute, M. von Wolff
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引用次数: 0

摘要

众所周知,克罗米芬柠檬酸盐(CC)可减少子宫内膜厚度,但尚不清楚额外的促性腺激素刺激是否会增加子宫内膜厚度以及这是否会对体外受精(IVF)的植入率产生影响。这项回顾性研究包括263个每天用25 mg CC刺激的最小刺激IVF周期(CC-IVF),以及161个每天用CC加75IU hMG(人类更年期促性腺激素)刺激的IVF周期。分析第-4天至第0天(0=取卵日)的子宫内膜和雌二醇(E2)测量值,并在多次调整后研究子宫内膜厚度和治疗对植入率的影响。结果表明,在第0天,CC/hMG IVF周期的子宫内膜明显增厚(9.81±2.68对9.06±2.54mm,p=0.005)。然而,子宫内膜厚度的增加对植入率和活产率没有影响。总之,促性腺激素不应该仅仅为了增加子宫内膜厚度而添加到低剂量CC治疗的IVF周期中,因为增加的子宫内膜厚度不会增加植入率。
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Clomiphene citrate stimulated cycles – additional gonadotrophin stimulation increases endometrium thickness without increasing implantation rate
It is known that Clomiphene citrate (CC) reduces endometrial thickness, but it is unknown if additional gonadotrophin stimulation increases endometrial thickness and if this has an effect on implantation rate in in vitro fertilization (IVF). The retrospective study included 263 minimal stimulation IVF-cycles stimulated with 25 mg CC per day (CC- IVF), and 161 IVF-cycles stimulated with CC plus 75IU hMG (human Menopausal Gonadotrophin) per day (CC/ hMG-IVF). Endometrial and oestradiol (E2) measurements were analysed between day -4 and 0 (0 = day of oocyte retrieval) and the association of endometrial thickness and treatment on implantation rates were studied after multiple adjustments. It was shown that on day 0, endometrium was significantly thicker in CC/hMG-IVF versus CC-IVF cycles (9.81 ±2.68 versus 9.06 ±2.54 mm, p = 0.005). However, increased endometrial thickness did not have an effect on implantation and live birth rates. In conclusion, gonadotrophins should not be added to low dose CC treated IVF cycles just to increase endometrial thickness as increased endometrial thickness does not increase implantation rate.
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Facts Views and Vision in ObGyn
Facts Views and Vision in ObGyn OBSTETRICS & GYNECOLOGY-
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