葡萄糖转运蛋白在肿瘤疾病诊断和预后中的作用

IF 3.1 Q2 ONCOLOGY Oncology Reviews Pub Date : 2022-02-22 DOI:10.4081/oncol.2022.561
L. Szablewski
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引用次数: 12

摘要

细胞的主要代谢底物是葡萄糖,它在几个过程中既是能量的来源又是底物。然而,由于是亲脂性的,细胞膜对葡萄糖是不可渗透的,需要特定的载体蛋白来允许运输。与正常细胞相比,癌细胞更可能通过糖酵解产生能量;由于这一过程产生的三磷酸腺苷(ATP)分子少于完全氧化分解,因此需要更多的葡萄糖分子。癌细胞对葡萄糖的需求增加是通过一些葡萄糖转运蛋白的过度表达和其他转运蛋白水平的降低来满足的。由于已经观察到癌症的发生与葡萄糖载体蛋白的表达之间存在特定的相关性,因此葡萄糖转运蛋白表达的变化可能被视为癌症患者诊断和/或预后的标志。
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Glucose transporters as markers of diagnosis and prognosis in cancer diseases
The primary metabolic substrate for cells is glucose, which acts as both a source of energy and a substrate in several processes. However, being lipophilic, the cell membrane is impermeable to glucose and specific carrier proteins are needed to allow transport. In contrast to normal cells, cancer cells are more likely to generate energy by glycolysis; as this process generates fewer molecules of adenosine triphosphate (ATP) than complete oxidative breakdown, more glucose molecules are needed. The increased demand for glucose in cancer cells is satisfied by overexpression of a number of glucose transporters, and decreased levels of others. As specific correlations have been observed between the occurrence of cancer and the expression of glucose carrier proteins, the presence of changes in expression of glucose transporters may be treated as a marker of diagnosis and/or prognosis for cancer patients.
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来源期刊
Oncology Reviews
Oncology Reviews ONCOLOGY-
CiteScore
6.30
自引率
0.00%
发文量
9
审稿时长
9 weeks
期刊介绍: Oncology Reviews is a quarterly peer-reviewed, international journal that publishes authoritative state-of-the-art reviews on preclinical and clinical aspects of oncology. The journal will provide up-to-date information on the latest achievements in different fields of oncology for both practising clinicians and basic researchers. Oncology Reviews aims at being international in scope and readership, as reflected also by its Editorial Board, gathering the world leading experts in both pre-clinical research and everyday clinical practice. The journal is open for publication of supplements, monothematic issues and for publishing abstracts of scientific meetings; conditions can be obtained from the Editor-in-Chief or the publisher.
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