{"title":"car - t细胞治疗后表现为蛋白性淋巴结病","authors":"Mishi Bhushan, Kirthi R. Kumar","doi":"10.1016/j.ehpc.2021.200475","DOIUrl":null,"url":null,"abstract":"<div><p>Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma and is often treated with chemotherapy, autologous stem cell transplant, and chimeric antigen receptor (CAR-T) cell therapy. Despite the increasing use of CAR-T therapy in various hematolymphoid malignancies, very little is known about pathologic effects on various tissues. We report a case of diffuse large B-cell lymphoma treated with CAR-T, with suspected relapse on PET scan. Pathology from an excisional biopsy showed no evidence of persistent diffuse large B-cell lymphoma, but instead showed extensive deposition of PAS positive, acellular material, consistent with proteinaceous lymphadenopathy. There is little known pathologic effects on malignant tissue following CAR-T therapy and we present one such undocumented finding of post-CAR-T cell therapy-induced proteinaceous lymphadenopathy.</p></div>","PeriodicalId":38075,"journal":{"name":"Human Pathology: Case Reports","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ehpc.2021.200475","citationCount":"0","resultStr":"{\"title\":\"Post-CAR-T cell therapy presenting as proteinaceous lymphadenopathy\",\"authors\":\"Mishi Bhushan, Kirthi R. Kumar\",\"doi\":\"10.1016/j.ehpc.2021.200475\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma and is often treated with chemotherapy, autologous stem cell transplant, and chimeric antigen receptor (CAR-T) cell therapy. Despite the increasing use of CAR-T therapy in various hematolymphoid malignancies, very little is known about pathologic effects on various tissues. We report a case of diffuse large B-cell lymphoma treated with CAR-T, with suspected relapse on PET scan. Pathology from an excisional biopsy showed no evidence of persistent diffuse large B-cell lymphoma, but instead showed extensive deposition of PAS positive, acellular material, consistent with proteinaceous lymphadenopathy. There is little known pathologic effects on malignant tissue following CAR-T therapy and we present one such undocumented finding of post-CAR-T cell therapy-induced proteinaceous lymphadenopathy.</p></div>\",\"PeriodicalId\":38075,\"journal\":{\"name\":\"Human Pathology: Case Reports\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.ehpc.2021.200475\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Human Pathology: Case Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2214330021000043\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Human Pathology: Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2214330021000043","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
Post-CAR-T cell therapy presenting as proteinaceous lymphadenopathy
Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma and is often treated with chemotherapy, autologous stem cell transplant, and chimeric antigen receptor (CAR-T) cell therapy. Despite the increasing use of CAR-T therapy in various hematolymphoid malignancies, very little is known about pathologic effects on various tissues. We report a case of diffuse large B-cell lymphoma treated with CAR-T, with suspected relapse on PET scan. Pathology from an excisional biopsy showed no evidence of persistent diffuse large B-cell lymphoma, but instead showed extensive deposition of PAS positive, acellular material, consistent with proteinaceous lymphadenopathy. There is little known pathologic effects on malignant tissue following CAR-T therapy and we present one such undocumented finding of post-CAR-T cell therapy-induced proteinaceous lymphadenopathy.