一个小队列低水平HIV-1病毒血症患者的病毒学结果分析

IF 2.1 4区医学 Q3 VIROLOGY Future Virology Pub Date : 2022-07-27 DOI:10.2217/fvl-2021-0195

Lisha Ding, Xi Chen, Jian-mei He, Jun Zheng, Xiuqing Wei, Bi-yun Qin, Xiangzhong Li

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引用次数: 0

摘要

目的:目前尚不清楚hiv感染患者是否维持低水平病毒血症(LLV)状态。材料与方法:纳入hiv感染的LLV患者，随访5年。通过回归分析评估与病毒学结果相关的因素。结果:共有39例患者维持LLV状态，而19例患者出现病毒载量≥1000拷贝/ml的疾病进展。LLV持续时间和耐药性(DR)与病毒学失败相关。DR病例中最常见的突变是M184V/I(70.4%)和K103N(40.7%)。蛋白酶抑制剂(PI)突变是罕见的。结论:长期维持LLV的hiv -1感染患者发生病毒学失败的风险增加。DR在LLV患者中并不罕见。

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Analysis of virologic outcome in low-level HIV-1 viremia patients in a small cohort

Aim: It is unclear whether a low-level viremia (LLV) status is maintained in HIV-infected patients. Materials & methods: HIV-infected patients with LLV were enrolled and followed up for 5 years. Factors associated with virological outcomes were assessed via regression analyses. Results: A total of 39 patients maintained an LLV status, whereas 19 had disease progression with a viral load of ≥1000 copies/ml. LLV duration and drug resistance (DR) were associated with virological failure. Among the DR cases, the most frequent mutations were M184V/I (70.4%) and K103N (40.7%). Protease inhibitor (PI) mutations were rare. Conclusion: There is an increased risk for virologic failure in HIV-1-infected patients maintaining LLV for a long time. DR was not a rare phenomenon in LLV patients.

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来源期刊

Future Virology 医学-病毒学

CiteScore

4.00

自引率

3.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Future Virology is a peer-reviewed journal that delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this ever-expanding area of research. It is an interdisciplinary forum for all scientists working in the field today.