Mechanism of peripheral nerve modulation and recent applications

Abstract Neuromodulation is a multi-interdisciplinary field of neuroscience, neural engineering, and medicine in a complex, but a way of understanding. Recently, the interest and researches in this field have been attracted due to its promising applications such as bionic limbs and bioelectronic medicine. For easier entry into this field, in this review, we approach the basic mechanism, methods, and applications of peripheral neuromodulation sequentially. Firstly, the overall structure and functions of the human nervous system are introduced, especially in the peripheral nervous system (PNS). Specifically, the fundamental neurophysiology regarding action potentials and neural signals is introduced to understand the communication between the neurons. Thereafter, two main methods for peripheral neuromodulation, which are electrical and optogenetic approaches, are introduced with the principles of the state-of-art devices. Finally, advanced applications of neuromodulation combined with the sensor, stimulator, and controller, called a closed-loop system are introduced with an example of bionic limbs.