干粉玫瑰果湿造粒制片工艺研究

M. Špaglová, M. Matušková, M.K. Lawson, M. Čuchorová, M. Čierna, D. Krchňák, V. Mikušová, J. Piešťanský, P. Mikuš
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引用次数: 0

摘要

摘要狗玫瑰的伪果富含L-抗坏血酸和其他几种活性物质,具有很高的支持治疗潜力。本研究旨在检验含有玫瑰果粉的片剂的制备工艺对最终药物形式中L-抗坏血酸含量的影响。植物药物在室温下干燥,以避免这种热敏化合物可能的热降解。类似地,在烘箱中湿法造粒后的颗粒干燥被室温下的自然干燥所代替。两种制备的颗粒制剂的成分在填料方面有所不同——乳糖(LAC)或微晶纤维素(MCC)。除崩解试验外,它们还符合颗粒或片剂的工艺要求。乳糖被证实是一种更合适的填充剂,尽管颗粒崩解不成功,但即使不添加起崩解剂作用的特殊赋形剂,乳糖也能确保片剂在15分钟内崩解。LAC片和MCC片中的L-抗坏血酸含量分别为87.16±5.06µg和63.33±2.83µg。
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Technological Processing of Dried Powdered Rosehips to Tablets Through Wet Granulation
Abstract The pseudo-fruits of Dog Rose are a rich source of L-ascorbic acid and several other active substances, which means their high supportive therapeutic potential. The study aimed to examine the impact of the chosen technological procedure for the preparation of tablets containing rosehip powder on the amount of L-ascorbic acid in the final pharmaceutical form. Drying of the plant drug was performed at room temperature to avoid possible thermal degradation of this heat-sensitive compound. Similarly, drying of the granules after wet granulation in the oven was replaced by natural drying at room temperature. The composition of two types of prepared granule formulations differed in the filler – lactose (LAC) or microcrystalline cellulose (MCC). Apart from the disintegration test, they meet the technological requirements for granules or tablets. Lactose was confirmed as a more suitable filler, which despite the unsuccessful disintegration of the granules, ensures the disintegration of tablets within 15 minutes even without the addition of a special excipient acting as a disintegrant. The content of L-ascorbic acid detected using isotachophoresis – capillary zone electrophoresis was 87.16 ± 5.06 µg in LAC tablets and 63.33 ± 2.83 µg in MCC tablets.
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来源期刊
European Pharmaceutical Journal
European Pharmaceutical Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
0.60
自引率
0.00%
发文量
16
期刊介绍: European Pharmaceutical Journal publishes only original articles not previously published and articles that are not being considered or have not been submitted for publication elsewhere. If parts of the results have been published as conference abstract or elsewhere, it should be stated in references. The ethical standards of the Helsinki-Tokio Declaration should be kept. This should be mentioned in the Methods of manuscript. Reviews are published only on request. Authors, whose submitted research work was performed with the support of a company, should indicate this in Conflict of Interest.
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