Yu. S. Lukina, B. P. Mishchenko, V. V. Zaytsev, M. G. Vasilev, I. I. Selezneva
{"title":"在明显再生过程条件下，基于骨基质的抗破骨细胞吸收的骨塑材料作为rhBMP的载体","authors":"Yu. S. Lukina, B. P. Mishchenko, V. V. Zaytsev, M. G. Vasilev, I. I. Selezneva","doi":"10.1134/S2075113322040244","DOIUrl":null,"url":null,"abstract":"<p>A technology has been developed for obtaining and evaluating in model studies in vitro a chemically fixed xenogenic bone matrix structurally resistant to osteoclastic resorption. The parameters of demineralization of the fragmented bone matrix have been selected in which the complete removal of the mineral component is carried out with the preservation of collagen in its native state. Optimal technological parameters of chemical fixation with epoxy compounds make it possible to obtain a stable material with free epoxy groups which can serve as a carrier for recombinant protein growth factors (rhBMP) in conditions of a pronounced regenerative process.</p>","PeriodicalId":586,"journal":{"name":"Inorganic Materials: Applied Research","volume":"13 4","pages":"952 - 960"},"PeriodicalIF":0.5000,"publicationDate":"2022-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Osteoplastic Material Based on a Bone Matrix Resistant to Osteoclastic Resorption under Conditions of a Pronounced Regenerative Process as a Carrier for rhBMP\",\"authors\":\"Yu. S. Lukina, B. P. Mishchenko, V. V. Zaytsev, M. G. Vasilev, I. I. Selezneva\",\"doi\":\"10.1134/S2075113322040244\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>A technology has been developed for obtaining and evaluating in model studies in vitro a chemically fixed xenogenic bone matrix structurally resistant to osteoclastic resorption. The parameters of demineralization of the fragmented bone matrix have been selected in which the complete removal of the mineral component is carried out with the preservation of collagen in its native state. Optimal technological parameters of chemical fixation with epoxy compounds make it possible to obtain a stable material with free epoxy groups which can serve as a carrier for recombinant protein growth factors (rhBMP) in conditions of a pronounced regenerative process.</p>\",\"PeriodicalId\":586,\"journal\":{\"name\":\"Inorganic Materials: Applied Research\",\"volume\":\"13 4\",\"pages\":\"952 - 960\"},\"PeriodicalIF\":0.5000,\"publicationDate\":\"2022-07-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Inorganic Materials: Applied Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S2075113322040244\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Inorganic Materials: Applied Research","FirstCategoryId":"1085","ListUrlMain":"https://link.springer.com/article/10.1134/S2075113322040244","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
Osteoplastic Material Based on a Bone Matrix Resistant to Osteoclastic Resorption under Conditions of a Pronounced Regenerative Process as a Carrier for rhBMP
A technology has been developed for obtaining and evaluating in model studies in vitro a chemically fixed xenogenic bone matrix structurally resistant to osteoclastic resorption. The parameters of demineralization of the fragmented bone matrix have been selected in which the complete removal of the mineral component is carried out with the preservation of collagen in its native state. Optimal technological parameters of chemical fixation with epoxy compounds make it possible to obtain a stable material with free epoxy groups which can serve as a carrier for recombinant protein growth factors (rhBMP) in conditions of a pronounced regenerative process.
期刊介绍：
Inorganic Materials: Applied Research contains translations of research articles devoted to applied aspects of inorganic materials. Best articles are selected from four Russian periodicals: Materialovedenie, Perspektivnye Materialy, Fizika i Khimiya Obrabotki Materialov, and Voprosy Materialovedeniya and translated into English. The journal reports recent achievements in materials science: physical and chemical bases of materials science; effects of synergism in composite materials; computer simulations; creation of new materials (including carbon-based materials and ceramics, semiconductors, superconductors, composite materials, polymers, materials for nuclear engineering, materials for aircraft and space engineering, materials for quantum electronics, materials for electronics and optoelectronics, materials for nuclear and thermonuclear power engineering, radiation-hardened materials, materials for use in medicine, etc.); analytical techniques; structure–property relationships; nanostructures and nanotechnologies; advanced technologies; use of hydrogen in structural materials; and economic and environmental issues. The journal also considers engineering issues of materials processing with plasma, high-gradient crystallization, laser technology, and ultrasonic technology. Currently the journal does not accept direct submissions, but submissions to one of the source journals is possible.
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