估计头发皮质醇水平作为牛皮癣慢性应激的生物标志物:一项初步研究

L. Budamakuntla, E. Loganathan, Heera Ramesh, Priyanka Karagaiah, S. Somashekhar, Shankar Kumar Venkatarayaraju
{"title":"估计头发皮质醇水平作为牛皮癣慢性应激的生物标志物:一项初步研究","authors":"L. Budamakuntla, E. Loganathan, Heera Ramesh, Priyanka Karagaiah, S. Somashekhar, Shankar Kumar Venkatarayaraju","doi":"10.4103/cdr.cdr_27_22","DOIUrl":null,"url":null,"abstract":"Background: Psychological stress can exacerbate many inflammatory diseases like psoriasis by dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis. One method of establishing this correlation is by measuring cortisol levels. Deposition of cortisol in the hair during its growth allows for retrospective quantification and to analyze the relationship between hair cortisol levels, stress, and psoriasis. Objective: The objective of this study is to evaluate hair cortisol levels as a biomarker of chronic stress in psoriasis patients. Materials and Methods: Detailed clinical and personal history and stress-related events before the onset of the disease or any exacerbations during the disease were taken. Clinical severity was assessed using psoriasis area and severity index (PASI) scoring. Stress levels in individuals, during the previous 6 months were assessed, using Holmes–Rahe Life Stress Inventory. Following this, hair samples were collected from the vertex of the scalp and sent to the laboratory in an envelope. After extraction of the cortisol, their levels were estimated using an enzyme-linked immunosorbent assay. Statistical analyses were done. Results: Mean hair cortisol level per mg of hair sample was 0.92 ± 0.84 ng/mg compared to 0.50 ± 0.60 ng/mg in controls (P = 0.002). There was a significant positive correlation of hair cortisol levels with the duration of disease, PASI score, and stress level. Conclusion: Measurement of cortisol in hair is a novel, noninvasive method that may assess systemic cortisol levels over several weeks to months. It may potentially be used as a biomarker in psychocutaneous disorders like psoriasis.","PeriodicalId":34880,"journal":{"name":"Clinical Dermatology Review","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Estimation of hair cortisol levels as a biomarker of chronic stress in psoriasis: A pilot study\",\"authors\":\"L. Budamakuntla, E. Loganathan, Heera Ramesh, Priyanka Karagaiah, S. Somashekhar, Shankar Kumar Venkatarayaraju\",\"doi\":\"10.4103/cdr.cdr_27_22\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Psychological stress can exacerbate many inflammatory diseases like psoriasis by dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis. One method of establishing this correlation is by measuring cortisol levels. Deposition of cortisol in the hair during its growth allows for retrospective quantification and to analyze the relationship between hair cortisol levels, stress, and psoriasis. Objective: The objective of this study is to evaluate hair cortisol levels as a biomarker of chronic stress in psoriasis patients. Materials and Methods: Detailed clinical and personal history and stress-related events before the onset of the disease or any exacerbations during the disease were taken. Clinical severity was assessed using psoriasis area and severity index (PASI) scoring. Stress levels in individuals, during the previous 6 months were assessed, using Holmes–Rahe Life Stress Inventory. Following this, hair samples were collected from the vertex of the scalp and sent to the laboratory in an envelope. After extraction of the cortisol, their levels were estimated using an enzyme-linked immunosorbent assay. Statistical analyses were done. Results: Mean hair cortisol level per mg of hair sample was 0.92 ± 0.84 ng/mg compared to 0.50 ± 0.60 ng/mg in controls (P = 0.002). There was a significant positive correlation of hair cortisol levels with the duration of disease, PASI score, and stress level. Conclusion: Measurement of cortisol in hair is a novel, noninvasive method that may assess systemic cortisol levels over several weeks to months. It may potentially be used as a biomarker in psychocutaneous disorders like psoriasis.\",\"PeriodicalId\":34880,\"journal\":{\"name\":\"Clinical Dermatology Review\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Dermatology Review\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/cdr.cdr_27_22\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Dermatology Review","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/cdr.cdr_27_22","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

背景:心理应激可通过调节下丘脑-垂体-肾上腺(HPA)轴而使银屑病等炎症性疾病恶化。建立这种相关性的一种方法是测量皮质醇水平。毛发生长过程中皮质醇的沉积可以进行回顾性量化,并分析毛发皮质醇水平、压力和牛皮癣之间的关系。目的:本研究的目的是评估毛发皮质醇水平作为银屑病患者慢性应激的生物标志物。材料和方法:详细的临床和个人病史以及发病前或疾病期间任何恶化的压力相关事件。采用银屑病面积和严重程度指数(PASI)评分评估临床严重程度。使用Holmes-Rahe生活压力量表评估个体在前6个月的压力水平。在此之后,从头皮顶点收集头发样本,并将其装在信封里送到实验室。提取皮质醇后,使用酶联免疫吸附法估计其水平。进行了统计分析。结果:毛发样本的平均皮质醇水平为0.92±0.84 ng/mg,对照组为0.50±0.60 ng/mg (P = 0.002)。毛发皮质醇水平与病程、PASI评分和应激水平呈正相关。结论:测量头发中的皮质醇是一种新颖的、无创的方法,可以评估几周到几个月的全身皮质醇水平。它可能被用作牛皮癣等精神皮肤疾病的生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Estimation of hair cortisol levels as a biomarker of chronic stress in psoriasis: A pilot study
Background: Psychological stress can exacerbate many inflammatory diseases like psoriasis by dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis. One method of establishing this correlation is by measuring cortisol levels. Deposition of cortisol in the hair during its growth allows for retrospective quantification and to analyze the relationship between hair cortisol levels, stress, and psoriasis. Objective: The objective of this study is to evaluate hair cortisol levels as a biomarker of chronic stress in psoriasis patients. Materials and Methods: Detailed clinical and personal history and stress-related events before the onset of the disease or any exacerbations during the disease were taken. Clinical severity was assessed using psoriasis area and severity index (PASI) scoring. Stress levels in individuals, during the previous 6 months were assessed, using Holmes–Rahe Life Stress Inventory. Following this, hair samples were collected from the vertex of the scalp and sent to the laboratory in an envelope. After extraction of the cortisol, their levels were estimated using an enzyme-linked immunosorbent assay. Statistical analyses were done. Results: Mean hair cortisol level per mg of hair sample was 0.92 ± 0.84 ng/mg compared to 0.50 ± 0.60 ng/mg in controls (P = 0.002). There was a significant positive correlation of hair cortisol levels with the duration of disease, PASI score, and stress level. Conclusion: Measurement of cortisol in hair is a novel, noninvasive method that may assess systemic cortisol levels over several weeks to months. It may potentially be used as a biomarker in psychocutaneous disorders like psoriasis.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
审稿时长
45 weeks
期刊最新文献
Pulse Therapy in Rituximab Era: A Retrospective Study of 124 Patients of Pemphigus from a Tertiary Care Center of South Rajasthan A Baby with Café-au-lait Macules and Aberrant Mongolian Spot: Report of Phakomatosis Pigmentopigmentaria Reactive Infectious Mucocutaneous Eruption with Extensive Cutaneous Involvement Orofacial Granulomatosis Secondary to Cutaneous Tuberculosis: An Atypical Presentation Mucocutaneous Manifestations among Patients with Malignancies at a Tertiary Care Center in Maharashtra: A Cross-Sectional Study
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1