局部给予菲律宾无刺蜂(Tetragonula biroi Friese)蜂蜜消除ICR小鼠急性炎症

IF 0.7 Q4 PHARMACOLOGY & PHARMACY Pharmacognosy Research Pub Date : 2023-02-22 DOI:10.5530/pres.15.2.028
M. J. Desamero, Mikaela Bernadette Andres Rabino, Maria Angelica Rimas Tayao, M. Ang, J. Bariuan, Roxanne P. Gapasin, T. M. Collantes, M. M. R. Rondina, C. Fernandez-Colorado, C. Cervancia, M. Estacio
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引用次数: 0

摘要

背景:蜂蜜是一种甜的富含糖的蜜蜂衍生产品,在阿育吠陀和生药学领域被广泛认可用于治疗各种炎症性疾病,包括炎症性肠病、哮喘、关节炎和胃溃疡。然而,从当地无刺蜜蜂获得的菲律宾蜂蜜的抗炎作用仍未被探索和调查。因此,本研究通过λ-卡拉胶诱导的小鼠足跖水肿模型,深入研究了局部应用菲律宾无刺蜜蜂蜂蜜(PSH)的抗炎潜力。材料与方法:选取6周龄雄性ICR小鼠30只,随机分为蒸馏水组、1%双氯芬酸钠组和蜂蜜处理组,每组10只。所有治疗均在卡拉胶注射后立即进行,然后在24小时的试验期间每8小时进行一次。结果:与蒸馏水处理组相比,在诱导后6小时(pi)开始至24小时(pi)时,用卡拉胶反复局部应用PSH显著减轻了观察到的总后爪肿胀。这在组织学上对应于真皮厚度、真皮水肿和白细胞浸润的显著减少。然而,在细胞因子水平上,这与循环血液中促炎细胞因子、TNF-α、IL-1β和IL-6水平的显著抑制相关。结论:基于这些结果,菲律宾无刺蜂蜂蜜显示出令人信服的抗炎活性,部分是通过调节炎症相关细胞因子的表达来介导的。
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Abrogation of Acute Inflammation in ICR Mice with Topical Administration of Philippine Stingless Bee (Tetragonula biroi Friese) Honey
Background: Honey, a sweet sugar-rich bee-derived product, has been widely recognized in the realm of Ayurveda and Pharmacognosy for the treatment of various inflammatory conditions including inflammatory bowel disease, asthma, arthritis, and gastric ulcer. However, the anti-inflammatory effect of Philippine honey obtained from local stingless bees remains unexplored and poorly investigated. Hence, this study delved on the anti-inflammatory potential of topically applied Philippine stingless bee honey (PSH) using the λ-Carrageenan-induced mouse model of paw edema. Materials and Methods: A total of 30, male ICR mice of six weeks of age were randomly divided into the following groups ( n =10 per group) as follows: Distilled water, 1% Diclofenac sodium, and Honey-treated group. All treatments were administered immediately after Carrageenan injection and then every 8 hr during the 24-hr test duration. Results: Repeated topical application of PSH significantly attenuated the gross hind paw swelling observed at the onset of the 6 hr post-induction ( pi ) until the 24 hr pi with Carrageenan in contrast to the Distilled water-treated group. This corresponded histologically to a marked reduction in dermal thickness, dermal edema, and leukocytic infiltration. Whereas, at the cytokine level, this correlated to significant suppression of the circulating blood levels of pro-inflammatory cytokines, TNF-α, IL-1β, and IL-6. Conclusion: Based on these results, honey from the Philippine stingless bees shows convincing anti-inflammatory activity which is partly mediated through the regulation of the expression of inflammation-associated cytokines.
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来源期刊
Pharmacognosy Research
Pharmacognosy Research PHARMACOLOGY & PHARMACY-
自引率
14.30%
发文量
61
期刊介绍: Pharmacognosy Research [ISSN: Print -0976-4836, Online - 0974-8490] [http://www.phcogres.com], Quarterly a publication of Phcog.Net is published by Wolters Kluwer - Medknow Publications. It provides peer-reviewed original research articles from the field of Natural Products. The journal serves an international audience of scientists and researchers in a variety of research and academia by quickly disseminating research findings related to Medicinal Plants and Natural Products. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submissions of original contributions in all areas of pharmacognosy are welcome.
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