北阿坎德邦医护人员对严重急性呼吸系统综合征冠状病毒2型疫苗的抗体反应:一项前瞻性随访研究

IF 0.2 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Indian Journal of Community Health Pub Date : 2023-03-31 DOI:10.47203/ijch.2023.v35i01.018
G. Mittal, Rajender Singh, M. Mittal, Shagufta Jahoor, Preeti Bisht, B. Kakati
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引用次数: 0

摘要

背景:世界各国目前正在竞相为人们接种导致新冠肺炎的严重急性呼吸系统综合征冠状病毒2型疫苗。印度政府还从2021年1月16日开始开展疫苗接种活动。目的:估计接种疫苗的医护人员中以SARS-COV-2 IgG抗体形式接种的新冠肺炎疫苗的抗体反应。方法:对北阿坎德邦德拉敦一所医学院的医护人员进行前瞻性随访。已接种新冠肺炎疫苗的医护人员定期接受SARS-CoV-2-IgG抗体检测,即在第一剂接种后4周,然后在第二剂接种后四周再次检测。第三个样本是在第二次给药6个月后采集的。结果:共有302名HCW参与了这项研究,他们在接种Covishield疫苗后提供了IgG抗体评估样本。两种剂量完成4周后,96%的HCW形成了严重急性呼吸系统综合征冠状病毒2型IgG抗体,而4%没有。随后,经过6个月的随访,14%的HCW抗体呈阴性,在此期间感染新冠肺炎的人免疫力更好。结论:这项研究得出结论,接种疫苗后获得的免疫力在大约6个月内逐渐减弱,需要加强针,尤其是对高危人群。感染控制措施在预防这种致命疾病方面仍然发挥着至关重要的作用。
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Antibody Response to SARS-COV-2 Vaccination in Healthcare Workers of Uttarakhand: A Prospective Follow-up Study
Background: Countries around the world are now racing to vaccinate people against SARS-CoV-2, the virus that causes COVID-19. The Government of India also rolled out its vaccination drive from 16th January ‘2021. Aims: To estimate the antibody response of the COVID-19 vaccine in the form of SARS-COV-2 IgG antibodies in vaccinated healthcare workers. Methods: Prospective follow-up was study conducted on healthcare workers (HCWs) of a Medical college in Dehradun, Uttarakhand. Healthcare workers who have been vaccinated for COVID-19 were tested for SARS-CoV-2-IgG antibodies at regular intervals i.e at 4 weeks after the 1st dose and then again at 4 weeks after the 2nd dose. The third sample was taken 6 months after the 2nd dose. Results: A total of 302 HCWs were enrolled in the study who gave their samples for IgG antibody estimation after the Covishield vaccine. After 4 weeks of completion of both doses, 96% HCWs formed SARS-COV-2 IgG antibodies, whereas 4% didn’t. Then after 6 months of follow-up, 14% HCWs have become negative for antibodies and better immunity is seen in people who also got infected with COVID-19 during this time. Conclusion: This study concludes that the immunity gained after vaccination is waning off in around 6 months and there is a need for a booster dose, especially for people at high risk. The infection control practices still play a crucial role in the prevention of this deadly disease.
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来源期刊
Indian Journal of Community Health
Indian Journal of Community Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
CiteScore
0.60
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0.00%
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89
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