基于表面模具涂抹器的近距离放射治疗早期阴茎癌病例的分步指南:器官保存方法

P. Thakur, M. Gupta, R. Gupta, Tarunjot Singh, N. Parihar, Asha Ranjan
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摘要

意图 在本报告中,我们讨论了一种单独定制的表面模具敷贴器技术来治疗一例早期阴茎癌。本病例报告描述了基于正交X射线技术的近距离放射治疗计划。材料和方法 应用表面模具敷贴技术治疗T1N0病伴鳞状细胞癌,组织学累及阴茎包皮和阴茎头。使用藻酸盐对器官进行印模。使用4型石膏从印模制备铸件。基于丙烯酸模具的涂敷器是在铸件上制造的。将导管放置并固定在丙烯酸模具上。将器官放置在基于模具的涂抹器中,并在二维成像上重建导管。近距离放射治疗通过使用Ir192源的18通道高剂量率Oncentra近距离放射疗法进行。给药剂量为45 Gy,分为15个部分,每天两次,超过6次 间隔数小时。后果 患者在6周后接受随访,溃疡完全消退。目前,该患者在过去的10个月里一直在接受随访,目前已无病。结论 通过明智的患者选择,表面霉菌近距离治疗是间质近距离治疗的一种有吸引力的替代方案。它让患者感到舒适,易于重复,并且在高工作负载和有限资源设置下节省时间。这项技术的早期结果是有希望的。
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Step-by-Step Guide to Surface Mold Applicator-Based Brachytherapy in a Case of Early Carcinoma Penis: An Organ-Preserving Approach
Purpose In this report we discuss an individually customized surface mold applicator technique to treat a case of early carcinoma penis. This case report is one of its kind which describes the brachytherapy treatment planning based on orthogonal X-ray technique. Material and methods T1N0 disease with squamous cell carcinoma histology involving the foreskin of penis and abutting the glans penis was treated by surface mold applicator technique. Impression of the organ was taken using alginate. Cast was prepared from the impression using Type 4 gypsum. The acrylic mold-based applicator was fabricated on the cast. The catheters were positioned and fixed on the acrylic mold. The organ is placed in the mold-based applicator and the catheters are reconstructed on two-dimensional imaging. The brachytherapy is delivered by the 18-channel high-dose rate Oncentra brachytherapy using Ir192 source. The dose given was 45 Gy in 15 fractions, twice daily more than 6 hours apart. Results Patient was reviewed after 6 weeks for follow-up and there was complete regression of the ulcer. At present, patient is on follow-up for the last 10 months and is now disease-free. Conclusion With judicious patient selection, surface mold brachytherapy is an attractive alternative to the interstitial brachytherapy. It is comfortable for the patient, is easily repeatable, and is time saving in high work load and limited resource settings. Early results with this technique are promising.
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