Higher Regulatory Control of Tramadol to Prevent its Abuse and Dependence

Abstract Tramadol abuse potential is not well studied. While some studies claim low abuse potential, others signal significant public health risks associated with tramadol abuse. This is a review on the abuse and dependence potential of tramadol. Tramadol was originally approved as non-controlled drug, but there is a trend to recognize tramadol as a controlled substance by regulators in many countries. Several factors contribute to abuse of tramadol. The leading reasons include history of drug abuse, geographical variation, and lessened regulatory controls. Tramadol abuse can cause increases in seizures and suicidal ideations. Abusers experience withdrawal symptoms and worsening of depression. Higher regulatory control of tramadol is warranted to avoid its misuse.