褪黑素治疗对慢性紧张型头痛患者头痛及血管舒缩反应性的影响

IF 0.4 4区 医学 Q4 NEUROSCIENCES Neurological Sciences and Neurophysiology Pub Date : 2021-01-01 DOI:10.4103/nsn.nsn_7_21
E. Eroğlu, B. Öztürk, A. Özön, G. Koc, Ö. Karadaş
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引用次数: 0

摘要

目的:慢性紧张型头痛(TTH)是一种严重影响生活质量的疾病。在这项研究中,根据国际头痛疾病分类标准,研究了预防性口服褪黑素治疗对诊断为慢性TTH的患者头痛和脑血管舒缩反应性(VMR)的影响。受试者和方法:本研究包括20名慢性TTH患者和20名健康人。患者接受了为期12周的3 mg/天褪黑素治疗。在治疗前后用“视觉模拟量表”记录每月疼痛天数和疼痛严重程度。在基线时对对照组和治疗前后的患者进行大脑VMR测量。结果:治疗前每月疼痛天数中位数为20天(15-27天),治疗后每月疼痛天数中值为10天(4-18天);中位疼痛严重程度评分在治疗前为70.00(45-80),治疗后为42.50(15-75)。差异有统计学意义(P=0.001)。VMR值之间无统计学意义(P>0.05)。结论:褪黑素治疗可有效降低慢性TTH患者的疼痛程度和每月疼痛天数,但对大脑VMR无影响。
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The effects of melatonin treatment on headache and vasomotor reactivity in patients with chronic tension-type headache
Objectives: Chronic tension-type headache (TTH) is a serious disease that disrupts quality of life. In this study, the effect of prophylactic oral melatonin treatment on headache and cerebral vasomotor reactivity (VMR) was investigated in patients diagnosed with chronic TTH per the International Classification of Headache Disorders criteria. Subjects and Methods: Twenty patients with chronic TTH and 20 healthy individuals were included in the study. The patients were administered a melatonin treatment at 3 mg/day for 12 weeks. The number of monthly painful days and pain severity were recorded with the “Visual Analog Scale” before and after the treatment. Cerebral VMR measurements were performed at baseline in the control group and in patients before and after the treatment. Results: The median number of monthly painful days was 20 (15–27) before the treatment and 10 (4–18) after the treatment; the median pain severity score was 70.00 (45–80) before the treatment and 42.50 (15–75) after the treatment. The difference was statistically significant (P = 0.001). No statistically significant difference between the VMR values was observed (P > 0.05). Conclusions: Melatonin treatment was effective in reducing the pain severity and decreasing the number of monthly painful days in patients with chronic TTH but demonstrated no effect on the cerebral VMR.
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来源期刊
CiteScore
0.70
自引率
25.00%
发文量
4
审稿时长
26 weeks
期刊介绍: Neurological Sciences and Neurophysiology is the double blind peer-reviewed, open access, international publication organ of Turkish Society of Clinical Neurophysiology EEG-EMG. The journal is a quarterly publication, published in March, June, September and December and the publication language of the journal is English.
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