Vanessa Spano , Cary M. Springer , E’Lise Christensen , Julia D. Albright
{"title":"米氮平透皮和加巴喷丁作为收容所猫访视前药物的作用","authors":"Vanessa Spano , Cary M. Springer , E’Lise Christensen , Julia D. Albright","doi":"10.1016/j.jveb.2023.06.001","DOIUrl":null,"url":null,"abstract":"<div><p>Humane medical handling of fearful felines<span><span> in the shelter is a challenge for staff. Gabapentin<span> has entered into clinical use to attenuate fear and anxiety in cats during handling, but restraint for pilling can be dangerous for the handler and contribute to fear responses in the cat. Administering pre-veterinary visit pharmaceuticals to cats with minimal stress remains elusive. Transdermal medications, which require minimal handling, may improve compliance. While no transdermal anxiolytics have shown a sufficient pharmacodynamic effect in cats, transdermal </span></span>mirtazapine<span> has entered into use for appetite stimulation. This double-blinded, placebo-controlled study assessed (1) the effect of transdermal mirtazapine on the amount of gabapentin-laced food ingested, and (2) the effect of gabapentin on signs of fear and anxiety in cats when handled for examination. To test this, 94 healthy shelter cats were randomly assigned to one of five treatment groups. Data collected included the amount of food consumed, estimated gabapentin dose consumed where applicable, and physiologic and behavioral parameters during examination. Cats pre-treated with transdermal placebo consumed significantly less gabapentin-laced food than cats pre-treated with transdermal mirtazapine. While there was a significant inverse relationship between estimated gabapentin dose consumed and heart rate and respiratory rate, the addition of transdermal mirtazapine counteracted these effects. No other significant relationships were found between treatments and the remaining measurements. While pre-treatment transdermal mirtazapine allowed for easier administration of gabapentin, its stimulating effects may have counteracted gabapentin’s anxiolytic effects. Future research should investigate reliable, minimally stressful methods for administering pre-veterinary visit pharmaceuticals to shelter cats.</span></span></p></div>","PeriodicalId":17567,"journal":{"name":"Journal of Veterinary Behavior-clinical Applications and Research","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Effects of transdermal mirtazapine and oral gabapentin as pre-veterinary visit pharmaceuticals for shelter cats\",\"authors\":\"Vanessa Spano , Cary M. Springer , E’Lise Christensen , Julia D. Albright\",\"doi\":\"10.1016/j.jveb.2023.06.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Humane medical handling of fearful felines<span><span> in the shelter is a challenge for staff. Gabapentin<span> has entered into clinical use to attenuate fear and anxiety in cats during handling, but restraint for pilling can be dangerous for the handler and contribute to fear responses in the cat. Administering pre-veterinary visit pharmaceuticals to cats with minimal stress remains elusive. Transdermal medications, which require minimal handling, may improve compliance. While no transdermal anxiolytics have shown a sufficient pharmacodynamic effect in cats, transdermal </span></span>mirtazapine<span> has entered into use for appetite stimulation. This double-blinded, placebo-controlled study assessed (1) the effect of transdermal mirtazapine on the amount of gabapentin-laced food ingested, and (2) the effect of gabapentin on signs of fear and anxiety in cats when handled for examination. To test this, 94 healthy shelter cats were randomly assigned to one of five treatment groups. Data collected included the amount of food consumed, estimated gabapentin dose consumed where applicable, and physiologic and behavioral parameters during examination. Cats pre-treated with transdermal placebo consumed significantly less gabapentin-laced food than cats pre-treated with transdermal mirtazapine. While there was a significant inverse relationship between estimated gabapentin dose consumed and heart rate and respiratory rate, the addition of transdermal mirtazapine counteracted these effects. No other significant relationships were found between treatments and the remaining measurements. While pre-treatment transdermal mirtazapine allowed for easier administration of gabapentin, its stimulating effects may have counteracted gabapentin’s anxiolytic effects. Future research should investigate reliable, minimally stressful methods for administering pre-veterinary visit pharmaceuticals to shelter cats.</span></span></p></div>\",\"PeriodicalId\":17567,\"journal\":{\"name\":\"Journal of Veterinary Behavior-clinical Applications and Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2023-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Veterinary Behavior-clinical Applications and Research\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1558787823000679\",\"RegionNum\":3,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"BEHAVIORAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Veterinary Behavior-clinical Applications and Research","FirstCategoryId":"97","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1558787823000679","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BEHAVIORAL SCIENCES","Score":null,"Total":0}
Effects of transdermal mirtazapine and oral gabapentin as pre-veterinary visit pharmaceuticals for shelter cats
Humane medical handling of fearful felines in the shelter is a challenge for staff. Gabapentin has entered into clinical use to attenuate fear and anxiety in cats during handling, but restraint for pilling can be dangerous for the handler and contribute to fear responses in the cat. Administering pre-veterinary visit pharmaceuticals to cats with minimal stress remains elusive. Transdermal medications, which require minimal handling, may improve compliance. While no transdermal anxiolytics have shown a sufficient pharmacodynamic effect in cats, transdermal mirtazapine has entered into use for appetite stimulation. This double-blinded, placebo-controlled study assessed (1) the effect of transdermal mirtazapine on the amount of gabapentin-laced food ingested, and (2) the effect of gabapentin on signs of fear and anxiety in cats when handled for examination. To test this, 94 healthy shelter cats were randomly assigned to one of five treatment groups. Data collected included the amount of food consumed, estimated gabapentin dose consumed where applicable, and physiologic and behavioral parameters during examination. Cats pre-treated with transdermal placebo consumed significantly less gabapentin-laced food than cats pre-treated with transdermal mirtazapine. While there was a significant inverse relationship between estimated gabapentin dose consumed and heart rate and respiratory rate, the addition of transdermal mirtazapine counteracted these effects. No other significant relationships were found between treatments and the remaining measurements. While pre-treatment transdermal mirtazapine allowed for easier administration of gabapentin, its stimulating effects may have counteracted gabapentin’s anxiolytic effects. Future research should investigate reliable, minimally stressful methods for administering pre-veterinary visit pharmaceuticals to shelter cats.
期刊介绍:
Journal of Veterinary Behavior: Clinical Applications and Research is an international journal that focuses on all aspects of veterinary behavioral medicine, with a particular emphasis on clinical applications and research. Articles cover such topics as basic research involving normal signaling or social behaviors, welfare and/or housing issues, molecular or quantitative genetics, and applied behavioral issues (eg, working dogs) that may have implications for clinical interest or assessment.
JVEB is the official journal of the Australian Veterinary Behaviour Interest Group, the British Veterinary Behaviour Association, Gesellschaft fr Tierverhaltensmedizin und Therapie, the International Working Dog Breeding Association, the Pet Professional Guild, the Association Veterinaire Suisse pour la Medecine Comportementale, and The American Veterinary Society of Animal Behavior.