精准医学及其在脓毒症治疗中的作用:个性化观点

IF 0.9 Q4 CRITICAL CARE MEDICINE Journal of Critical Care Medicine Pub Date : 2019-07-01 DOI:10.2478/jccm-2019-0017
A. Lazăr, A. Georgescu, A. Vitin, L. Azamfirei
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引用次数: 20

摘要

摘要近年来,一种新的医学形式变得越来越重要,即个性化医学(PM)。PM是一种针对个别患者量身定制的治疗方式。PM是关于使用多个数据集来创建数字人体映射。一个人的生物学特征是由数百个基因和基因网络的相互作用,以及饮食和锻炼等外部因素决定的。将这些多个数据库与强大的统计工具相结合,然后进行调查,可以对基因复杂性如何驱动健康和疾病有一个新的理解,从而形成一种更接近个性化的医疗方法,针对每个人独特的基因构成。败血症是一种对感染的全身炎症反应,从全身炎症反应综合征(SIRS)到感染性休克和多器官功能障碍综合征(MODS)。败血症是重症监护患者最常见的死亡原因。重症监护室的治疗可能需要适应疾病的持续快速变化,这使得确定单一靶点具有挑战性。因此,PM被视为ICU败血症治疗的未来。个体患者对治疗的反应不同,这一事实应被视为提供治疗方法的起点。这种疾病本身是次要的概念。
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Precision Medicine and its Role in the Treatment of Sepsis: A Personalised View
Abstract In recent years, a new form of medicine has become increasingly significant, namely, personalised medicine (PM). PM is a form of care in which treatment is tailored for an individual patient. PM is about using multiple data sets to create a digital human mapping. A person’s biological traits are determined by the interactions of hundreds of genes and gene networks, as well as external factors such as diet and exercise. Combining and then investigating these multiple databases with powerful statistical tools, allows a new understanding of how genetic intricacy drives health and disease and so leads to a closer personalised medical approach that targets each individual’s unique genetic make-up. Sepsis is a systemic inflammatory response to infection, ranging from systemic inflammatory response syndrome (SIRS) to septic shock and multiple organ dysfunction syndromes (MODS). Sepsis is the most common cause of death in intensive care patients. Treatments in an ICU may need to be adapted to the continuous and rapid changes of the disease, making it challenging to identify a single target. PM is thus seen as the future of sepsis treatment in the ICU. The fact that individual patients respond differently to treatment should be regarded as a starting point in the approach to providing treatment. The disease itself comes secondary to this concept.
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来源期刊
Journal of Critical Care Medicine
Journal of Critical Care Medicine CRITICAL CARE MEDICINE-
CiteScore
2.00
自引率
9.10%
发文量
21
审稿时长
11 weeks
期刊最新文献
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