两匹Percheron马的多糖储存性肌病

M. B. S. Teixeira, G. R. Bonatto, T. G. Cristo, Deise Hemckmeier, N. L. Pisetta, R. Casagrande
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摘要

多糖储存性肌病(PSSM)是一种遗传性疾病,其特征是骨骼肌纤维中糖原和多糖的异常积累,原因不明。本报告描述了两匹Percheron马,来自Pouso Redondo - SC市的不同属性,具有工作后开始的运动临床症状。临床表现为步态僵硬,以骨盆肢体为主,肌肉无力,平卧。在第一例病例中,动物被诊断为严重的多灶性横纹肌坏死,中度的多灶性肌红蛋白肾病和严重的弥漫性跨壁纤维蛋白坏死性胃炎。周期性酸-希夫(PAS)染色显示肌纤维肌膜中存在多糖包涵体,证实了PSSM。在第二个病例中,马在工作后出现了两次肌肉紊乱。治疗方案以青霉素、氟尼新、大明和乳酸林格液为主。血清生化评价中肌酸激酶(669.0 UI/L)和天冬氨酸转氨酶(669.0 UI/L)升高。对GYS1基因进行突变研究,结果为杂合子阳性。在休息和逐渐恢复后,马只接受轻度工作,此后没有恢复临床状态。因此,本报告描述两例PSSM具有不同的临床演变和诊断方法。
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Polysaccharide storage myopathy in two Percheron horses
Polysaccharide storage myopathy (PSSM) is a genetic disorder or by undetermined cause characterized by the abnormal accumulation of glycogen and polysaccharides in skeletal muscle fibers. The present report describes two Percheron horses, from different properties in the municipality of Pouso Redondo - SC, with locomotor clinical signs that started after work. The clinical signs observed were rigid gait, mainly of the pelvic limbs, muscle weakness, and recumbency. In the first case, the animal was diagnosed with severe multifocal rhabdomyonecrosis, moderate multifocal myoglobin nephrosis and severe diffuse transmural fibrinonecrotic gastritis. PSSM was confirmed by the presence of polysaccharide inclusions in myofiber sarcolemma visualized by periodic acid-Schiff (PAS) staining. In the second case, the horse presented two episodes of muscle disorder after work. The therapeutic protocol was based on penicillin, flunixin meglumine and fluid therapy with ringer lactate. An increase in creatine kinase (669.0 UI/L) and aspartate aminotransferase (669.0 UI/L) was observed in the serum biochemical evaluation. Research for mutation in the GYS1 gene was performed, with a positive heterozygote result. After rest and gradual recovery, the horse was only submitted to light work, with no return of the clinical condition since then. Thus, this report describes two cases of PSSM with distinct clinical evolution and diagnostic methods.
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来源期刊
Revista de Ciencias Agroveterinarias
Revista de Ciencias Agroveterinarias Veterinary-Veterinary (all)
CiteScore
0.50
自引率
0.00%
发文量
41
审稿时长
53 weeks
期刊介绍: Revista de Ciências Agroveterinárias (Journal of Agroveterinary Sciences) (ISSN 2238-1171) focus on publishing original and unpublished tecnical-scientific works regarding on researches in Agrarian and Veterinary Sciences and related areas. The objective of this journal is to publish double-blind peer reviewed research articles, research notes, and review articles contributing significantly for scientific knowledge diffusion and socialization, being made available to libraries of education and research institutions performing scientific activities on plants, animals, and related organisms.
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