Effects of Chromium, Inositol and Resistant Starch Supplementation In Pcos: A Systematic Review

Polycystic ovary syndrome (PCOS) is a diverse condition that has distinct signs and symptoms such as hyperandrogenism and chronic anovulation. It is a major hormonal disorder that affects the health-related quality of life and mental health of young women. The etiology of PCOS still remains uncertain but insulin resistance is one of the major factors seen in PCOS individuals which are characterized by the presence of acanthosis nigricans. Dietary interventions and lifestyle modification are being considered to be a first-line treatment for women with PCOS. Proper diet, adequate nutritional status, and following a physical activity routine help in alleviating the symptoms of PCOS. Dietary interventions should focus on weight management and insulin regulation. An abnormal gut microbiome function results in ovarian dysfunction, immune changes, insulin resistance, and disruption in bile synthesis. Therefore, gut health of women suffering from PCOS should be prioritized and interventions that improve the gut health should be followed. This systematic review is performed to investigate the association between micronutrient supplementation and PCOS. The related articles were searched using the databases PubMed, Science Direct, and Google Scholar. All the studies involving micronutrient supplementation and PCOS were included in this systematic review. Micronutrient supplementation was significantly inversely associated with improving PCOS prognosis. The main finding of the systematic review is that it concludes there is a direct association between micronutrient supplementation as it helps in alleviating the symptoms and maintaining a proper lifestyle in women with PCOS.