TRIM28作为一种新的转录延伸因子

IF 2.946 Q3 Biochemistry, Genetics and Molecular Biology BMC Molecular Biology Pub Date : 2015-08-21 DOI:10.1186/s12867-015-0040-x
Heeyoun Bunch, Stuart K Calderwood
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引用次数: 41

摘要

TRIM28是一种多结构域蛋白,在转录和DNA修复中具有多种功能。最近有研究表明,该因子在转录延伸中起着意想不到的作用。TRIM28被证明可以稳定许多未激活基因转录起始位点附近的RNA聚合酶II (Pol II)的暂停,允许Pol II积累并为诱导基因做好准备。此外,该因子被证明对伴随转录激活的信号反应迅速,允许先前暂停的Pol II的RNA的生产延伸。我们在这里讨论了TRIM28在转录控制和DNA修复中的关键调控机制,这可能阐明了该因子在Pol II暂停和延长中的新作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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TRIM28 as a novel transcriptional elongation factor

TRIM28 is a multidomain protein with versatile functions in transcription and DNA repair. Recently it was shown that this factor plays unanticipated roles in transcriptional elongation. TRIM28 was shown to stabilize the pausing of RNA polymerase II (Pol II) close to the transcriptional start site in many unactivated genes, permitting Pol II accumulation and readying genes for induction. In addition, the factor was shown to respond rapidly to signals accompanying transcriptional activation permitting the productive elongation of RNA by previously paused Pol II. We discuss here critical regulatory mechanisms of TRIM28 in transcriptional control and DNA repair that may illuminate the novel roles of this factor in pausing and elongation of Pol II.

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来源期刊
BMC Molecular Biology
BMC Molecular Biology 生物-生化与分子生物学
CiteScore
4.80
自引率
0.00%
发文量
0
审稿时长
>12 weeks
期刊介绍: BMC Molecular Biology is an open access journal publishing original peer-reviewed research articles in all aspects of DNA and RNA in a cellular context, encompassing investigations of chromatin, replication, recombination, mutation, repair, transcription, translation and RNA processing and function.
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