食用燕窝对慢性脑灌注不足大鼠神经退行性变的神经保护作用

Rehab A. Ismaeil, C. K. Hui, K. Affandi, Batoul Alallam, Wael M. Y. Mohamed, M. Noor
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引用次数: 2

摘要

目的:阿尔茨海默病(AD)的特点是大脑供血不足,导致记忆力和认知能力的逐渐丧失。慢性脑灌注不足导致脑血流量持续减少,导致活性氧过量产生,从而引发炎症,导致认知能力下降。到目前为止,阿尔茨海默病还没有治愈的方法,唯一的选择是对症治疗。本研究通过大鼠慢性脑低灌注诱导的神经炎症模型,评估了食用燕窝(EBN)对海马神经元,特别是CA1海马区的影响。方法:双侧颈总动脉永久性闭塞(2VO)诱导大鼠慢性脑灌注不足(CCH),触发神经炎症过程。将大鼠分为4组:假手术组、2VO组和2个2VO组,分别给予2种不同剂量的EBN (60 mg/kg、120 mg/kg),每天灌胃。连续8周后,对大鼠实施安乐死,通过计数活神经元细胞对海马组织进行组织病理学检查,海马组织中F2Isoprostane水平为
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Neuroprotective effect of edible bird’s nest in chronic cerebral hypoperfusion induced neurodegeneration in rats
Aim: Alzheimer’s disease (AD) is marked by insufficient blood supply to the brain, leading to progressive loss of memory and cognitive skills. The continuous reduction of cerebral blood flow resulting from chronic cerebral hypoperfusion leads to the overproduction of reactive oxygen species that triggers inflammation, causing cognitive decline. Till now, there is no cure for AD and the only option is symptomatic treatment. The current study evaluates the effect of edible bird’s nest (EBN) on hippocampal neurons, specifically in the CA1 hippocampal region, by using a rat model of chronic cerebral hypoperfusion-induced neuroinflammation. Methods: Chronic cerebral hypoperfusion (CCH) was induced by permanent bilateral common carotid artery occlusion (2VO) in rats to trigger the neuroinflammatory process. Rats were divided into 4 groups: sham, 2VO, and two 2VO groups treated with two different doses (60 mg/kg, 120 mg/kg) of EBN, which was administered daily by oral gavage. After 8 consecutive weeks, rats were euthanized and the hippocampi were examined histopathologically by counting viable neuronal cells and the levels of F2Isoprostane in hippocampal tissue was
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