Synthesis, E/Z isomerisation and antimicrobial studies of different structured novel ketone derivatives.

In this study five different structured mono ketones’ ( k1- k5 ) novel derivatives as five new   hydrazones ( h1-h5 ) and   five new semicarbazones ( s1-s5 ) were synthesized.  The synthesized compounds were identified by IR, 1 H-NMR, 13 C-NMR, mass and chromatographic methods for their structures and E/Z isomerizations.  These mentioned hydrazones and semicarbazones were investigated for their antimicrobial activities.  Seven bacterias and three fungis were tested. Ciprofloxacin and Fluconazole were used as standards. MIC values were determined. The relationship between structure and antimicrobial actvity was discussed. Hydrazones were more effective than semicarbazones. Besides, acetyl acetone as a diketone delivered the known 1-(2,4-dinitrophenyl)-3,5-dimethyl-1H-pyrazole ( p1 ) which showed very high antimicrobial activity than hydrazones and semicarbazones against Klebsiella pneumoniae ATCC 4352, Proteus mirabilis ATCC 14153, Staphylococcus epidermidis ATCC 12228, Enterococcus faecalis ATCC 29212, Candida parapsilosis ATCC 22019, Candida tropicalis ATCC 750.