东北红豆杉内生真菌青霉HDS-Z-1E的代谢产物及其对过氧化氢酶的激活作用

IF 4.7 4区 医学 Q1 CHEMISTRY, MEDICINAL Chinese Herbal Medicines Pub Date : 2024-04-01 DOI:10.1016/j.chmed.2022.12.009
Chuan Tang, Rui Gao, Xiaoyuan Tang, Yu Zhang, Weixing Feng, Baomin Feng, Xuan Lu
{"title":"东北红豆杉内生真菌青霉HDS-Z-1E的代谢产物及其对过氧化氢酶的激活作用","authors":"Chuan Tang,&nbsp;Rui Gao,&nbsp;Xiaoyuan Tang,&nbsp;Yu Zhang,&nbsp;Weixing Feng,&nbsp;Baomin Feng,&nbsp;Xuan Lu","doi":"10.1016/j.chmed.2022.12.009","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>To study the compounds isolated from <em>Penicillium</em> HDS-Z-1E, an endophytic fungal strain isolated from <em>Taxus cuspidata</em> and their activation effect of catalase (CAT).</p></div><div><h3>Methods</h3><p>The chemical constituents were isolated from <em>Penicillium</em> HDS-Z-1E, by using silica gel, Sephadex LH-20 and HPLC. The structural elucidations of five metabolites were elucidated on the basis of spectroscopic including <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, HMBC and HSQC. Their activation sites of catalase have been investigated by molecular docking.</p></div><div><h3>Results</h3><p>Five metabolites, compounds (<strong>1</strong>–<strong>5</strong>) were isolated from <em>Penicillium</em> HDS-Z-1E and identified as 4-hydroxy-4-methyltetrahydro-2<em>H</em>-pyran-2-one (<strong>1</strong>), 4-hydroxymethyl-5, 6-dihydro-pyran-2-one (<strong>2</strong>), 5, 6-dihydro-2-oxo-2<em>H</em>-pyran-4-carboxylic (<strong>3</strong>), <em>N</em>-acetyl-hydrazinobenzoic acid (<strong>4</strong>), and methyl 2-(2, 5-dihydroxyphenyl) acetate (<strong>5</strong>).</p></div><div><h3>Conclusion</h3><p>Compound <strong>3</strong> is a new compound. Compounds <strong>3</strong> and <strong>4</strong> may have potential activators of catalase, providing a theoretical basis for the development of CAT activators.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":null,"pages":null},"PeriodicalIF":4.7000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638423000515/pdfft?md5=33e6a3b81bc02850668e73681a37affc&pid=1-s2.0-S1674638423000515-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Metabolites isolated from Penicillium HDS-Z-1E, an endophytic fungal strain isolated from Taxus cuspidata and their activation effect of catalase\",\"authors\":\"Chuan Tang,&nbsp;Rui Gao,&nbsp;Xiaoyuan Tang,&nbsp;Yu Zhang,&nbsp;Weixing Feng,&nbsp;Baomin Feng,&nbsp;Xuan Lu\",\"doi\":\"10.1016/j.chmed.2022.12.009\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>To study the compounds isolated from <em>Penicillium</em> HDS-Z-1E, an endophytic fungal strain isolated from <em>Taxus cuspidata</em> and their activation effect of catalase (CAT).</p></div><div><h3>Methods</h3><p>The chemical constituents were isolated from <em>Penicillium</em> HDS-Z-1E, by using silica gel, Sephadex LH-20 and HPLC. The structural elucidations of five metabolites were elucidated on the basis of spectroscopic including <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, HMBC and HSQC. Their activation sites of catalase have been investigated by molecular docking.</p></div><div><h3>Results</h3><p>Five metabolites, compounds (<strong>1</strong>–<strong>5</strong>) were isolated from <em>Penicillium</em> HDS-Z-1E and identified as 4-hydroxy-4-methyltetrahydro-2<em>H</em>-pyran-2-one (<strong>1</strong>), 4-hydroxymethyl-5, 6-dihydro-pyran-2-one (<strong>2</strong>), 5, 6-dihydro-2-oxo-2<em>H</em>-pyran-4-carboxylic (<strong>3</strong>), <em>N</em>-acetyl-hydrazinobenzoic acid (<strong>4</strong>), and methyl 2-(2, 5-dihydroxyphenyl) acetate (<strong>5</strong>).</p></div><div><h3>Conclusion</h3><p>Compound <strong>3</strong> is a new compound. Compounds <strong>3</strong> and <strong>4</strong> may have potential activators of catalase, providing a theoretical basis for the development of CAT activators.</p></div>\",\"PeriodicalId\":9916,\"journal\":{\"name\":\"Chinese Herbal Medicines\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2024-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1674638423000515/pdfft?md5=33e6a3b81bc02850668e73681a37affc&pid=1-s2.0-S1674638423000515-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chinese Herbal Medicines\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1674638423000515\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chinese Herbal Medicines","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1674638423000515","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0

摘要

方法 利用硅胶、Sephadex LH-20 和 HPLC 从青霉 HDS-Z-1E 中分离出化学成分。通过 1H-NMR、13C-NMR、HMBC 和 HSQC 等光谱分析,阐明了五种代谢物的结构。通过分子对接研究了它们对过氧化氢酶的激活位点。结果从青霉 HDS-Z-1E 中分离出五种代谢物化合物(1-5),并鉴定为 4-羟基-4-甲基四氢-2H-吡喃-2-酮(1)、4-羟甲基-5、6-二氢吡喃-2-酮 (2)、5, 6-二氢-2-氧代-2H-吡喃-4-羧酸 (3)、N-乙酰基肼基苯甲酸 (4) 和 2-(2,5-二羟基苯基) 乙酸甲酯 (5)。结论化合物 3 是一种新化合物。化合物 3 和 4 可能是过氧化氢酶的潜在激活剂,为开发 CAT 激活剂提供了理论依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Metabolites isolated from Penicillium HDS-Z-1E, an endophytic fungal strain isolated from Taxus cuspidata and their activation effect of catalase

Objective

To study the compounds isolated from Penicillium HDS-Z-1E, an endophytic fungal strain isolated from Taxus cuspidata and their activation effect of catalase (CAT).

Methods

The chemical constituents were isolated from Penicillium HDS-Z-1E, by using silica gel, Sephadex LH-20 and HPLC. The structural elucidations of five metabolites were elucidated on the basis of spectroscopic including 1H-NMR, 13C-NMR, HMBC and HSQC. Their activation sites of catalase have been investigated by molecular docking.

Results

Five metabolites, compounds (15) were isolated from Penicillium HDS-Z-1E and identified as 4-hydroxy-4-methyltetrahydro-2H-pyran-2-one (1), 4-hydroxymethyl-5, 6-dihydro-pyran-2-one (2), 5, 6-dihydro-2-oxo-2H-pyran-4-carboxylic (3), N-acetyl-hydrazinobenzoic acid (4), and methyl 2-(2, 5-dihydroxyphenyl) acetate (5).

Conclusion

Compound 3 is a new compound. Compounds 3 and 4 may have potential activators of catalase, providing a theoretical basis for the development of CAT activators.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Chinese Herbal Medicines
Chinese Herbal Medicines CHEMISTRY, MEDICINAL-
CiteScore
4.40
自引率
5.30%
发文量
629
审稿时长
10 weeks
期刊最新文献
HPLC combined with chemometrics for quality control of Huamoyan Granules or Capsules Constituents from leaves of Macaranga hemsleyana Chemical constituents, pharmacological activities and quality evaluation methods of genus Hippocampus: A comprehensive review Ethnopharmacology, chemical composition and functions of Cymbopogon citratus Bioactive components, pharmacological properties and underlying mechanism of Ganoderma lucidum spore oil: A review
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1