低分割放疗时代如何处理低氧与放疗的关系

Q4 Health Professions Iranian Journal of Radiation Research Pub Date : 2021-10-10 DOI:10.29242/IJRR.19.4.759
H. Gao, Y. Wan, X. Bu, X. Fan, X. Xie, X. Ji, W. Song
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引用次数: 0

摘要

缺氧是实体瘤中的一种常见现象,可促进功能失调的血管生长和上皮向间充质的转变,导致细胞迁移和转移。低氧肿瘤细胞对电离辐射的敏感性降低是影响常规放疗效果的主要因素之一。众所周知,常规放射治疗主要通过部分之间的复氧来降低低氧辐射抵抗的影响。随着放射治疗计划和实施的改进,越来越多的癌症患者接受了低分割放疗(HFRT)治疗,其疗效远高于常规放疗。考虑到HFRT是在一个或几个部分内递送的,肿瘤缺氧会影响其疗效吗?有什么方法可以进一步提高HFRT的效果吗?在这篇综述中,我们重点讨论了HFRT与缺氧之间的相互作用,并详细讨论了如何优化HFRT的方案以减少缺氧的影响并提高疗效。
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How to deal with the relationship between hypoxia and radiotherapy in the hypofractionated radiotherapy era
Hypoxia, a common phenomenon in solid tumors can promote dysfunctional vascular growth and epithelial-to-mesenchymal transition, leading to cell mobility and metastasis. The decreased sensitivity of hypoxic tumor cells to ionizing radiation is one of the main factors affecting the effect of conventional radiotherapy. It is well known that conventional radiotherapy mainly reduces the effect of hypoxic radiation resistance by reoxygenation between fractions. With the improvement of radiation treatment planning and delivery, more and more cancer patients have been treated with hypofractionated radiotherapy (HFRT), which have achieved a much higher effect than conventional radiotherapy. Given that HFRT is delivered within one or a few fractions, does tumor hypoxia affect its efficacy? Is there any way to further improve the effect of HFRT? In this review, we focus on the interaction between HFRT and hypoxia, and how to optimize the regimen of HFRT to decrease the effect of hypoxia and improve the efficacy is discussed in detail.
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来源期刊
Iranian Journal of Radiation Research
Iranian Journal of Radiation Research RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
0.67
自引率
0.00%
发文量
0
审稿时长
>12 weeks
期刊介绍: Iranian Journal of Radiation Research (IJRR) publishes original scientific research and clinical investigations related to radiation oncology, radiation biology, and Medical and health physics. The clinical studies submitted for publication include experimental studies of combined modality treatment, especially chemoradiotherapy approaches, and relevant innovations in hyperthermia, brachytherapy, high LET irradiation, nuclear medicine, dosimetry, tumor imaging, radiation treatment planning, radiosensitizers, and radioprotectors. All manuscripts must pass stringent peer-review and only papers that are rated of high scientific quality are accepted.
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