战胜印度糖尿病的战略研究框架:21世纪议程

IF 1.8 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Journal of the Indian Institute of Science Pub Date : 2023-03-21 DOI:10.1007/s41745-022-00354-5
K. M. Venkat Narayan, Jithin Sam Varghese, Yara S. Beyh, Soura Bhattacharyya, Shweta Khandelwal, Gokul S. Krishnan, Karen R. Siegel, Tinku Thomas, Anura V. Kurpad
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引用次数: 1

摘要

印度人患2型糖尿病(T2DM)的风险很高,即使在年轻和体重较轻的时候也是如此。印度已经有7400万人患有这种疾病,而且在社会各阶层中,2型糖尿病患者的比例正在增加。与胰岛素分泌或功能降低、肝脏脂肪沉积增加以及超重(与生活方式改变有关)相关的独特因素可能都是导致T2DM持续流行的原因。然而,印度对2型糖尿病的病因、病理生理、表型、预防、治疗和医疗保健服务的研究严重滞后。科学发现和技术创新有重大机遇,如果加以利用,可以为2型糖尿病提供符合本国国情的解决方案,并为全球科学做出主要贡献。我们分析了印度2型糖尿病的现状,并提出了一个四支柱(病因学、精准医学、实施研究和卫生政策)战略研究框架来应对这一挑战。我们为每个支柱提供关键研究问题,并确定基础设施需求。印度为将不精确的晚期糖尿病治疗模式转变为早期精确的预防和护理提供了肥沃的环境。投资和利用科学、工程和医学等学科的学术和技术基础设施,可以加速实现无糖尿病国家的目标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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A Strategic Research Framework for Defeating Diabetes in India: A 21st-Century Agenda

Indian people are at high risk for type 2 diabetes (T2DM) even at younger ages and lower body weights. Already 74 million people in India have the disease, and the proportion of those with T2DM is increasing across all strata of society. Unique aspects, related to lower insulin secretion or function, and higher hepatic fat deposition, accompanied by the rise in overweight (related to lifestyle changes) may all be responsible for this unrelenting epidemic of T2DM. Yet, research to understand the causes, pathophysiology, phenotypes, prevention, treatment, and healthcare delivery of T2DM in India seriously lags behind. There are major opportunities for scientific discovery and technological innovation, which if tapped can generate solutions for T2DM relevant to the country’s context and make leading contributions to global science. We analyze the situation of T2DM in India, and present a four-pillar (etiology, precision medicine, implementation research, and health policy) strategic research framework to tackle the challenge. We offer key research questions for each pillar, and identify infrastructure needs. India offers a fertile environment for shifting the paradigm from imprecise late-stage diabetes treatment toward early-stage precision prevention and care. Investing in and leveraging academic and technological infrastructures, across the disciplines of science, engineering, and medicine, can accelerate progress toward a diabetes-free nation.

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来源期刊
Journal of the Indian Institute of Science
Journal of the Indian Institute of Science MULTIDISCIPLINARY SCIENCES-
CiteScore
4.30
自引率
0.00%
发文量
75
期刊介绍: Started in 1914 as the second scientific journal to be published from India, the Journal of the Indian Institute of Science became a multidisciplinary reviews journal covering all disciplines of science, engineering and technology in 2007. Since then each issue is devoted to a specific topic of contemporary research interest and guest-edited by eminent researchers. Authors selected by the Guest Editor(s) and/or the Editorial Board are invited to submit their review articles; each issue is expected to serve as a state-of-the-art review of a topic from multiple viewpoints.
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