青菜的化学成分、体外抗氧化和抗糖尿病作用。F。

Q2 Agricultural and Biological Sciences Transactions of The Royal Society of South Africa Pub Date : 2022-05-04 DOI:10.1080/0035919X.2022.2102687
A. Ogundajo, S. Adeboye, Abib Olatunde, Wahab Badmus, M. Owolabi
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引用次数: 0

摘要

研究了青菜的化学成分及其抗氧化和抗糖尿病活性。F.采用冷萃取法分别获得了正己烷、乙酸乙酯和甲醇提取物。采用标准方法对提取物进行植物化学分析,采用体外测定法评估其抗氧化活性,并根据-淀粉酶和-葡萄糖苷酶的作用评估其抗糖尿病潜力。采用气相色谱-质谱联用(GC-MS)分析方法对提取物的化学成分进行了鉴定。甲醇提取物中苯酚(68.93 mg没食子酸g-1)和黄酮(74.84 mg槲皮素g-1)含量最高,乙酸乙酯提取物中原花青素(33.21 mg儿茶素g-1)含量最高。甲醇提取物对1,1-二苯基-2-苦味酰肼(DPPH)、羟基(OH)和2,2-氮基-双(3-乙基苯并噻唑啉(ABTS)自由基的抑制作用(IC50)分别为0.58、0.19和0.46 mg/mL,最大抑制浓度的一半(P < 0.05),而己烷提取物对金属螯合活性(P < 0.05)为0.06 mg/mL。与其他提取物和阿卡波糖相比,己烷提取物对-淀粉酶(2.54 mg/mL)和-葡萄糖苷酶(0.53 mg/mL)的抑制作用中等,显示出较好的抗糖尿病活性。正己烷提取物对-淀粉酶和-葡萄糖苷酶活性分别产生非竞争性和竞争性混合抑制模式。经GC-MS分析,甲醇提取物具有抗氧化和抗糖尿病活性的主要化学成分包括叶绿醇(7.26%)、正十六酸(5.95%)、石竹烯(1.70%)和橙花醇(2.22%)。青菜提取物含有活性植物化学物质,具有治疗糖尿病和氧化应激相关疾病的潜力。
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Chemical compositions, in vitro assessments of antioxidant and antidiabetic potentials of Cyanomentra vogelii Hook. F.
The study investigates the chemical composition and antioxidant and antidiabetic activities of Cyanomentra vogelii Hook. F. Hexane, ethylacetate and methanol extracts of C. vogelii were obtained using a cold extraction method. Phytochemical analysis of the extracts was achieved using standard methods: in vitro assays were employed to assess antioxidant activities while antidiabetic potentials were evaluated against the action of ?-amylase and ?-glucosidase. The chemical composition of the extract was identified using gas chromatography-mass spectrometry (GC-MS) analysis. The methanol extract of C. vogelii displayed the highest quantity of phenol (68.93 mg gallic acid g-1) and flavonoids (74.84 mg quercetin g-1), while the ethylacetate extract exhibited the highest content of proanthocyanidins (33.21 mg catechin g-1). The methanol extract exhibited significantly potent inhibition (P < .05) – more than hexane and ethylacetate extracts – against 1,1-diphenyl-2-picryl-hydrazyl (DPPH), hydroxyl (OH) and 2,2-azino-bis (3-ethylbenzothiazoline (ABTS) radicals at half maximal inhibitory concentrations (IC50) of 0.58, 0.19 and 0.46 mg/mL, respectively, while hexane extract showed higher metal chelating activity (P < .05) at 0.06 mg/mL. Hexane extract displayed better antidiabetic activities, as revealed by its moderate ?-amylase (2.54 mg/mL) and potent ?-glucosidase (0.53 mg/mL) inhibition compared to other extracts and acarbose. Mixed non-competitive and competitive modes of inhibition were elicited by the hexane extract against the activity of ?-amylase and ?-glucosidase, respectively. The major chemical components with reported antioxidant and antidiabetic activities identified from GC-MS analysis of the methanol extract include phytol (7.26%), n-hexadecanoic acid (5.95%), caryophyllene (1.70%) and nerolidol (2.22%). Cyanomentra vogelii extract contains active phytochemicals with therapeutic potential in the management of diabetes and oxidative stress-related diseases.
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来源期刊
Transactions of The Royal Society of South Africa
Transactions of The Royal Society of South Africa Agricultural and Biological Sciences-Agricultural and Biological Sciences (all)
CiteScore
2.80
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0.00%
发文量
15
期刊介绍: Transactions of the Royal Society of South Africa , published on behalf of the Royal Society of South Africa since 1908, comprises a rich archive of original scientific research in and beyond South Africa. Since 1878, when it was founded as Transactions of the South African Philosophical Society, the Journal’s strength has lain in its multi- and inter-disciplinary orientation, which is aimed at ‘promoting the improvement and diffusion of science in all its branches’ (original Charter). Today this includes natural, physical, medical, environmental and earth sciences as well as any other topic that may be of interest or importance to the people of Africa. Transactions publishes original research papers, review articles, special issues, feature articles, festschriften and book reviews. While coverage emphasizes southern Africa, submissions concerning the rest of the continent are encouraged.
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