普里什蒂纳儿童急性淋巴细胞B细胞白血病一例新病例

Q4 Medicine Acta Medica Bulgarica Pub Date : 2023-03-22 DOI:10.2478/amb-2023-0009

V. Graiqevci-Uka, E. Behluli, L. Spahiu, T. Liehr, G. Temaj

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引用次数: 0

摘要

摘要急性淋巴细胞白血病（ALL）是一种由骨髓细胞前体B或T细胞突变引起的恶性疾病。儿童急性淋巴细胞白血病（ALL）是儿童癌症的一种亚型，发病率为1/2000。在这里，我们呈现一个3岁女孩的新童年。由于CD45/19、CD10/19、CD3、CD8、CD10和CD19在母细胞的免疫组织化学分析中呈阳性，因此诊断为B-ALL具有致病性ETV6-RUNX1基因融合。患者根据标准方案BMF-ALL 2009进行治疗。有趣的是，患者的一位阿姨和一位爷爷也经历过恶性肿瘤，这可能被仔细解释为家族性癌症综合征的暗示。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A New Case of Childhood Acute Lymphoblastic B-Cell Leukemia from Pristina

Abstract Acute lymphoblastic leukemia (ALL) is a malignant disease caused by mutations in B- or T-cell precursors of bone marrow cells. Childhood acute lymphoblastic leukemia (ALL) is a subtype of pediatric cancer with a 1 in 2000 incidence. Here we present a new childhood ALL in a 3-year-old girl. As CD45/19, CD10/19, CD3, CD8, CD10, and CD19 were positive in immunohistochemically analyses of blast cells, a B-ALL was diagnosed with a causative ETV6-RUNX1 gene fusion. The patient was treated based on standard protocols BMF-ALL 2009. Interestingly, an aunt and a grandfather of the patient had experienced malignancies as well, which may be carefully interpreted as a hint on a familial cancer syndrome.

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来源期刊

Acta Medica Bulgarica Medicine-Medicine (all)

CiteScore

0.30

自引率

0.00%

发文量

审稿时长

25 weeks

期刊介绍： About 30 years ago - in 1973, on the initiative of the Publishing House „Medicine and Physical Culture", namely its former director Mr. Traian Ivanov, the Ministry of Health set up and accepted to subsidize a new medical magazine that was to be published only in the English language and had to reflect the status and the achievements of the Bulgarian medical science. Thus the language barrier was overcome and stable relations were established with the international medical society, large libraries, and university centers. The famous internationally known scientist professor Assen A. Hadjiolov was elected edition-in-chief by the first editorial staff and the magazine was named Acta Medica Bulgarica.