电氧化及高灵敏电化学探针的研制用于水中甾体11-脱氧皮质酮药物残留的痕量测定

IF 2.3 Q3 ELECTROCHEMISTRY International journal of electrochemistry Pub Date : 2022-05-04 DOI:10.1155/2022/2074908
W. T. Alsaggaf, M. El-Shahawi
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引用次数: 2

摘要

合成代谢雄性激素(AASs)是一类经常被竞争对手滥用的化合物,不幸的是被普通人群滥用,最近引起了国际关注。因此,对开发用于检测和/或测定AAS的低成本、精确、快速和简便的方案提出了非凡的要求。因此,目前的策略首次通过吸附微分脉冲阳极溶出伏安法(DP-ASV)和循环伏安法(CV)在宽pH范围(pH 2.0–10.0)的玻碳电极(GCE)上探索了21-羟基孕甾-4-烯-3,20-二酮,即11-脱氧皮质酮(DCS)AA药物类固醇的氧化还原特征。在pH 2时,DP-ASV和CV在优化pH 2–3时在0.4处显示出不可逆的阳极峰 V相对于Ag/AgCl电极。CV在0.4时的阳极峰值电流的依赖性 V在DCS药物的不同浓度和扫描速率下是EE型机制的电极耦合电子转移的特征。在优化参数下,所提出的策略允许对浓度范围为2.5-13.19的DCS进行量化 nM(0.83-4.36 ng mL−1),检测限(LOD)和定量限(LOQ)为9.3 × 10−1 nM(3.1 × 10−1 ng mL−1)和3.1 nM(1.02 ng mL−1)。相对标准偏差(RSD)为±3.93%(n = 5) 4.0 ng 达到mL−1 DCS。所建立的探针用于环境水中DCS残留的痕量测定,效果良好。几种常见的不同物种对DCS传感的干扰不显著,显示出良好的选择性。与已报道的DCS测定方法相比,所建立的探针具有良好的灵敏度、选择性、精密度和准确性,分析时间短,成本低。
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Electrooxidation and Development of a Highly Sensitive Electrochemical Probe for Trace Determination of the Steroid 11-Desoxycorticosterone Drug Residues in Water
Anabolic-androgenic steroids (AASs), a class of compounds frequently misused by competitors and unfortunately by the general population, have lately attracted international attention. Thus, extraordinary demands for developing low cost, precise, rapid, and facile protocols for detection and/or determination of AAS have arisen. Hence, the current strategy explores for the first time the redox features of 21-hydroxypregn-4-ene-3, 20-dione, namely, 11-desoxycorticosterone (DCS) AA drug steroid at a glassy-carbon electrode (GCE) in a wide pH range (pH 2.0–10.0) by adsorptive differential pulse-anodic stripping voltammetry (DP- ASV) and cyclic voltammetry (CV). At pH 2, DP-ASV and CV at the optimized pH 2–3 displayed an irreversible anodic peak at 0.4 V versus Ag/AgCl electrode. The dependency of the anodic peak current of the CV at 0.4 V at various concentrations and scan rate of the DCS drug was characteristic of an electrode-coupled electron transfer of EE type mechanism. At the optimized parameters, the proposed strategy allowed quantification of DCS in the concentration range 2.5 -13.19 nM (0.83-4.36 ng mL−1) with satisfactory limits of detection (LOD) and quantization (LOQ) of 9.3 × 10−1 nM (3.1 × 10−1 ng mL−1) and 3.1 nM (1.02 ng mL−1), respectively. A relative standard deviation (RSD) of ±3.93% (n = 5) at 4.0 ng mL−1 DCS was achieved. The established probe was fruitfully employed and validated for trace determination of DCS residues in environmental water. The interference of several common diverse species on DCS sensing was insignificant revealing good selectivity. The established probe exhibited good sensitivity, selectivity, precision, and accuracy, short analytical time, and low cost compared with the reported methods, for DCS determination.
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