可注射水凝胶用于脊髓损伤修复

Q1 Medicine Engineered regeneration Pub Date : 2022-12-01 DOI:10.1016/j.engreg.2022.09.001
Huan Wang , Hui Zhang , Zhongyu Xie , Keng Chen , Mengjun Ma , Yuejiao Huang , Minli Li , Zhaopeng Cai , Peng Wang , Huiyong Shen
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引用次数: 17

摘要

脊髓损伤(Spinal cord injury, SCI)常导致严重的机体功能损害,给患者和整个社会带来巨大的负担。许多策略,特别是生物材料,已被用于损伤修复。在各种生物材料中,可注射水凝胶因其可装载功能成分,无需手术即可注射到病变区域而备受关注。本文综述了近年来用于脊髓损伤修复的注射水凝胶的研究进展。我们首先介绍了脊髓损伤的病理生理学,揭示了脊髓损伤的临床表现机制,确定了脊髓损伤的治疗方案。然后,我们描述了聚合物的原始来源和形成水凝胶的交联方式。之后,我们将重点讨论可注射水凝胶的体内治疗策略和效果。最后,对注射水凝胶在脊髓损伤修复方面面临的挑战和前景进行了总结和讨论。我们相信这一综述将有助于进一步开发用于脊髓损伤修复的注射水凝胶。
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Injectable hydrogels for spinal cord injury repair

Spinal cord injury (SCI) often causes severe functional impairment of body, which leads to a huge burden to the patient and the whole society. Many strategies, especially biomaterials, have been employed for SCI repair. Among various biomaterials, injectable hydrogels have attracted much attention because of their ability to load functional components and be injected into the lesioned area without surgeries. In this review, we summarize the recent progress in injectable hydrogels for SCI repair. We firstly introduce the pathophysiology of SCI, which reveals the mechanism of clinical manifestations and determines the therapeutic schedule. Then, we describe the original sources of polymers and the crosslinking manners in forming hydrogels. After that, we focus on the in vivo therapeutic strategies and effects of injectable hydrogels. Finally, the recent challenges and future outlook of injectable hydrogel for SCI repair are concluded and discussed. We believe this review can be helpful and inspire the further development of injectable hydrogels for SCI repair.

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来源期刊
Engineered regeneration
Engineered regeneration Biomaterials, Medicine and Dentistry (General), Biotechnology, Biomedical Engineering
CiteScore
22.90
自引率
0.00%
发文量
0
审稿时长
33 days
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