眼睛中的胆碱酯酶活性?

Sandra Carolina Durán Cristiano
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引用次数: 0

摘要

视觉系统由神经系统通过神经递质调节,神经递质在视觉和眼睛功能中发挥着重要作用。其中一种神经递质是乙酰胆碱,这是一种发挥多种生物功能的关键分子。另一方面,负责乙酰胆碱水解的乙酰胆碱酯酶与胆碱能功能有关。然而,几项研究表明,乙酰胆碱酯酶除了具有酶功能外,还具有非催化功能。近年来,评估乙酰胆碱酯酶所有可能功能的重要性已得到证明。然而,有证据表明,眼睛中的胆碱酯酶活性可以调节眼睛前部和后部结构中的一些生物事件,从而调节视觉皮层中处理的视觉信息。因此,胆碱酯酶活性的评估可能是胆碱能活性改变的一个可能标志,不仅在眼部疾病中,而且在全身性疾病中也是如此。
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Cholinesterase activity in the eye?
The visual system is regulated by the nervous system through neurotransmitters, which play an important role in visual and ocular functions. One of those neurotransmitters is acetylcholine, a key molecule that plays a diversity of biological functions. On the other hand, acetylcholinesterase, the enzyme responsible for the hydrolysis of acetylcholine, is implicated in cholinergic function. However, several studies showed that in addition to their enzymatic functions, Acetylcholinesterase exerts non-catalytic functions. In recent years, the importance of evaluating all possible functions of acetylcholine-acetylcholinesterase has been evidenced. Nevertheless, there is evidence that suggests cholinesterase activity in the eye can regulate some biological events both in structures of the anterior and posterior segment of the eye and therefore in the visual information that is processed in the visual cortex. Hence, the evaluation of cholinesterase activity could be a possible marker of alterations in cholinergic activity not only in ocular disease but also in systemic diseases.
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来源期刊
Central nervous system agents in medicinal chemistry
Central nervous system agents in medicinal chemistry Psychology-Neuropsychology and Physiological Psychology
CiteScore
2.10
自引率
0.00%
发文量
21
期刊介绍: Central Nervous System Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new central nervous system agents. Containing a series of timely in-depth reviews written by leaders in the field covering a range of current topics, Central Nervous System Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.
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