Shoko Ito, Shin-ichiro Fujiwara, Tomoaki Yoshizawa, Kaori Hayatsu, K. Sekiguchi, Rui Murahashi, Hirotomo Nakashima, S. Matsuoka, T. Ikeda, Y. Toda, Shin-ichiro Kawaguchi, T. Nagayama, K. Umino, D. Minakata, H. Nakano, K. Morita, R. Yamasaki, M. Ashizawa, Chihiro Yamamoto, Kaoru Hatano, Kazuya Sato, K. Ohmine, Y. Kanda
{"title":"血液恶性肿瘤伴肿瘤溶解综合征的尿黄嘌呤结晶","authors":"Shoko Ito, Shin-ichiro Fujiwara, Tomoaki Yoshizawa, Kaori Hayatsu, K. Sekiguchi, Rui Murahashi, Hirotomo Nakashima, S. Matsuoka, T. Ikeda, Y. Toda, Shin-ichiro Kawaguchi, T. Nagayama, K. Umino, D. Minakata, H. Nakano, K. Morita, R. Yamasaki, M. Ashizawa, Chihiro Yamamoto, Kaoru Hatano, Kazuya Sato, K. Ohmine, Y. Kanda","doi":"10.2169/internalmedicine.9332-22","DOIUrl":null,"url":null,"abstract":"Tumor lysis syndrome (TLS) is a metabolic disorder caused by massive tumor lysis. Hypouricemic agents are administered to prevent TLS-related hyperuricemia and renal failure. We experienced three cases of urine xanthine crystals during TLS in patients with hematologic malignancies who received prophylactic febuxostat. Yellowish and pinkish deposits were observed in urinary tract catheters and urinary bags. Urine microscopy revealed that the deposits were xanthine crystals. In rapid tumor lysis, inhibition of xanthine oxidase can cause xanthine accumulation and urine xanthine crystallization. During TLS, urine xanthine crystals may be overlooked, so careful observation and management are required to avoid xanthine nephropathy.","PeriodicalId":77259,"journal":{"name":"Medicina interna (Bucharest, Romania : 1991)","volume":"61 1","pages":"3271 - 3275"},"PeriodicalIF":0.0000,"publicationDate":"2022-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Urine Xanthine Crystals in Hematologic Malignancies with Tumor Lysis Syndrome\",\"authors\":\"Shoko Ito, Shin-ichiro Fujiwara, Tomoaki Yoshizawa, Kaori Hayatsu, K. Sekiguchi, Rui Murahashi, Hirotomo Nakashima, S. Matsuoka, T. Ikeda, Y. Toda, Shin-ichiro Kawaguchi, T. Nagayama, K. Umino, D. Minakata, H. Nakano, K. Morita, R. Yamasaki, M. Ashizawa, Chihiro Yamamoto, Kaoru Hatano, Kazuya Sato, K. Ohmine, Y. Kanda\",\"doi\":\"10.2169/internalmedicine.9332-22\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Tumor lysis syndrome (TLS) is a metabolic disorder caused by massive tumor lysis. Hypouricemic agents are administered to prevent TLS-related hyperuricemia and renal failure. We experienced three cases of urine xanthine crystals during TLS in patients with hematologic malignancies who received prophylactic febuxostat. Yellowish and pinkish deposits were observed in urinary tract catheters and urinary bags. Urine microscopy revealed that the deposits were xanthine crystals. In rapid tumor lysis, inhibition of xanthine oxidase can cause xanthine accumulation and urine xanthine crystallization. During TLS, urine xanthine crystals may be overlooked, so careful observation and management are required to avoid xanthine nephropathy.\",\"PeriodicalId\":77259,\"journal\":{\"name\":\"Medicina interna (Bucharest, Romania : 1991)\",\"volume\":\"61 1\",\"pages\":\"3271 - 3275\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-04-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medicina interna (Bucharest, Romania : 1991)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2169/internalmedicine.9332-22\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicina interna (Bucharest, Romania : 1991)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2169/internalmedicine.9332-22","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Urine Xanthine Crystals in Hematologic Malignancies with Tumor Lysis Syndrome
Tumor lysis syndrome (TLS) is a metabolic disorder caused by massive tumor lysis. Hypouricemic agents are administered to prevent TLS-related hyperuricemia and renal failure. We experienced three cases of urine xanthine crystals during TLS in patients with hematologic malignancies who received prophylactic febuxostat. Yellowish and pinkish deposits were observed in urinary tract catheters and urinary bags. Urine microscopy revealed that the deposits were xanthine crystals. In rapid tumor lysis, inhibition of xanthine oxidase can cause xanthine accumulation and urine xanthine crystallization. During TLS, urine xanthine crystals may be overlooked, so careful observation and management are required to avoid xanthine nephropathy.
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