{"title":"海参根和根茎中两种新的螺甾醇苷。","authors":"Xiaomei Song, Yu-ze Li, Zilong Zhang, Wenli Huang, Huawei Zhang, Yi Jiang, Jianli Liu, Dongdong Zhang","doi":"10.25135/rnp.361.2207.2520","DOIUrl":null,"url":null,"abstract":": Two new spirostanol glycosides, thibetanosides J and K ( 1 and 2 ), along with three known ones ( 3 - 5 ) were isolated from the roots and rhizomes of Helleborus thibetanus . Their structures were elucidated by extensive use of spectroscopic techniques and chemical evidence. In this study, compounds 1 - 5 were evaluated for their cytotoxic activity against HCT116, A549 and HepG2 tumor cell lines. Among them, compound 1 exhibited moderate cytotoxicity against A549 cells (IC 50 7.69 ± 1.13 μM) and HepG 2 cells (IC 50 8.32 ± 2.63 μM). Compound 2 exhibited moderate cytotoxicity against HCT116 cells (IC 50 20.67 ± 1.06 μM).","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":" ","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2022-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Two New Spirostanol Glycosides from the Roots and Rhizomes of Helleborus thibetanus Franch.\",\"authors\":\"Xiaomei Song, Yu-ze Li, Zilong Zhang, Wenli Huang, Huawei Zhang, Yi Jiang, Jianli Liu, Dongdong Zhang\",\"doi\":\"10.25135/rnp.361.2207.2520\",\"DOIUrl\":null,\"url\":null,\"abstract\":\": Two new spirostanol glycosides, thibetanosides J and K ( 1 and 2 ), along with three known ones ( 3 - 5 ) were isolated from the roots and rhizomes of Helleborus thibetanus . Their structures were elucidated by extensive use of spectroscopic techniques and chemical evidence. In this study, compounds 1 - 5 were evaluated for their cytotoxic activity against HCT116, A549 and HepG2 tumor cell lines. Among them, compound 1 exhibited moderate cytotoxicity against A549 cells (IC 50 7.69 ± 1.13 μM) and HepG 2 cells (IC 50 8.32 ± 2.63 μM). Compound 2 exhibited moderate cytotoxicity against HCT116 cells (IC 50 20.67 ± 1.06 μM).\",\"PeriodicalId\":21053,\"journal\":{\"name\":\"Records of Natural Products\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2022-10-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Records of Natural Products\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.25135/rnp.361.2207.2520\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Records of Natural Products","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.25135/rnp.361.2207.2520","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Two New Spirostanol Glycosides from the Roots and Rhizomes of Helleborus thibetanus Franch.
: Two new spirostanol glycosides, thibetanosides J and K ( 1 and 2 ), along with three known ones ( 3 - 5 ) were isolated from the roots and rhizomes of Helleborus thibetanus . Their structures were elucidated by extensive use of spectroscopic techniques and chemical evidence. In this study, compounds 1 - 5 were evaluated for their cytotoxic activity against HCT116, A549 and HepG2 tumor cell lines. Among them, compound 1 exhibited moderate cytotoxicity against A549 cells (IC 50 7.69 ± 1.13 μM) and HepG 2 cells (IC 50 8.32 ± 2.63 μM). Compound 2 exhibited moderate cytotoxicity against HCT116 cells (IC 50 20.67 ± 1.06 μM).
期刊介绍：
Records of Natural Products is a journal of natural product chemistry. Reviews, book reviews, research papers and short reports are considered on the substances of plants, microbes and animals.
Discussions on the structure elucidation, synthesis of naturally occurring compounds and biological activity of natural compounds and plant extracts, biosynthesis of natural products and essential oils of aromatic plants as well as chemotaxonomy in the field of plants are welcomed in the journal.
All published research articles in Records of Natural Products have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by expert referees.
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