Assessment of Vestibular System and Balance Function in Patients with Pseudoexfoliation Syndrome

Introduction: This study aims to evaluate the balance and vestibular system of patients with pseudoexfoliation syndrome. Materials and Method: A prospective case–control study was performed in a university hospital. The study population consisted of 37 patients (16 patient group, 21 control group). The Modified Clinical Test of Sensory Interaction Balance was performed in four conditions: 1) eyes open, firm surface; 2) eyes closed, firm surface; 3) eyes closed, foam surface; and 4) eyes open, foam surface. The Equilibrium Score, Anteroposterior Stability Index, Mediolateral Stability Index were employed for all conditions in both groups. Scores were compared between and within groups. Additionally, the physical activity of the patients with pseudoexfoliation syndrome was assessed using questionnaires based on the Turkish versions of the Modified Falls Efficacy Scale and the Physical Activity Scale for the Elderly. Results: There were no significant differences in terms of stability index and equilibrium scores with eyes open or closed conditions between the two groups; the only difference was in the mean mediolateral stability index score in the eyes open, firm surface condition with low scores in the pseudoexfoliation group (p=0.01). In the group analysis, patients with pseudoexfoliation had a significant increase in the equilibrium scores when their eyes were closed in the firm and foam surface conditions (p=0.001 for both). Conclusion: The central nervous system redistributes its dependence on sensory information when vision is compromised in patients with pseudoexfoliation syndrome. Their somatosensory input might deteriorate in some way but not the vestibular system. Keywords: Dizziness; Glaucoma; Aged.