巨噬细胞来源的HMGB1作为致痛分子/治疗靶点在内脏疼痛中的作用

Pain Research Pub Date : 2019-03-30 DOI:10.11154/PAIN.34.24
Maho Tsubota, A. Kawabata
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引用次数: 0

摘要

越来越多的证据揭示了神经免疫串扰在神经源性炎症和与神经炎症相关的多种神经系统疾病中的关键作用。高迁移率组框1 (hmgb1)是损伤相关分子模式(DAMPs) /警报器之一,目前被认为是一种促炎/促伤害性分子,参与神经性和炎症性疼痛的发病机制。在这篇综述中,我们主要关注hmgb1在膀胱、胰腺和结肠内脏疼痛信号传导中的作用。在膀胱炎相关膀胱疼痛的啮齿动物模型中,巨噬细胞来源的hmgb1激活晚期糖基化终产物受体(RAGE),诱导NF - κ b依赖性胱硫氨酸- γ -裂解酶(一种产生h2s的酶)的过度表达,通过h2s / cav 3导致伤害感受器过度兴奋。2 t型钙通道与随后的膀胱疼痛。在肠易激综合征(IBS)小鼠模型中,巨噬细胞来源的hmgb1似乎也在伴随急性胰腺炎的胰腺疼痛和结肠疼痛的发展中发挥作用。因此,hmgb1被认为是参与膀胱、胰腺和结肠内脏疼痛信号传导的神经免疫串音的关键介质,可能作为治疗间质性膀胱炎/膀胱疼痛综合征、急性胰腺炎或IBS患者内脏疼痛的新治疗靶点。
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Role of macrophage–derived HMGB1 as an algogenic molecule ⁄ therapeutic target in visceral pain
Accumulating evidence sheds light on the crucial role of a neuroimmune crosstalk in neurogenic inflammation and diverse neurological diseases associated with neuro inflammation. High mobility group box 1 (HMGB 1 ), one of damage–associated molecular patterns (DAMPs) ⁄ alarmins, is now considered a pro–inflammatory ⁄ pro– nociceptive molecule, and participates in the pathogenesis of neuropathic and inflammatory pain. In this review, we focus on the role of HMGB 1 in visceral pain signaling in the bladder, pancreas and colon. In rodent models for cystitis–related bladder pain, macrophage–derived HMGB 1 activates the receptor for advanced glycation end– products (RAGE), and induces NF– κ B–dependent overexpression of cystathionine– γ –lyase, an H 2 S–generating enzyme, resulting in excessive excitation of nociceptors through the H 2 S ⁄ Ca v 3 . 2 T–type calcium channel pathway and subsequent bladder pain. The macrophage–derived HMGB 1 also appears to play a role in the development of pancreatic pain accompanying acute pancreatitis and of colonic pain in a mouse model for irritable bowel syndrome (IBS). Thus, HMGB 1 is considered a key mediator for a neuroimmune crosstalk involved in visceral pain signaling in the bladder, pancreas and colon, and may serve as a novel therapeutic target for treatment of visceral pain in patients with interstitial cystitis ⁄ bladder pain syndrome, acute pancreatitis or IBS.
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Pain Research
Pain Research CLINICAL NEUROLOGY-
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